...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of studies on alcohol and drugs. >Beneficial role of dietary folic acid on cholesterol and bile acid metabolism in ethanol-fed rats.
【24h】

Beneficial role of dietary folic acid on cholesterol and bile acid metabolism in ethanol-fed rats.

机译：日粮叶酸对乙醇喂养大鼠胆固醇和胆汁酸代谢的有益作用。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: Cholesterol metabolism is altered by chronic ethanol consumption. In previous articles, we demonstrated the anti-oxidant capacity of folic acid, which may be useful in the prevention of damage provoked by ethanol. We want to determine the effects of ethanol on cholesterol and bile metabolism and whether a folic acid-supplemented diet could change alterations provoked by a chronic ethanol intake in rats. METHOD: We used four experimental groups: (1) control, (2) alcohol, (3) alcohol supplemented with folic acid, and (4) control supplemented with folic acid. In all the experimental groups, we measured hepatic 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, and cholesterol and bile acids in serum, liver, bile, and feces. RESULTS: We have found that the alcohol-fed groups showed high hepatic HMG-CoA reductase activity, total hepatic and serum cholesterol concentration, bile cholesterol secretion concentration, and cholesterol enterohepatic circulation. Total serum and hepatic cholesterol levels decreased when alcohol-fed rats were supplemented with folic acid. The hepatic bile acid concentration increased in both chronic ethanol groups. Folic acid supplementation significantly increased bile cholesterol secretion, the bile acids in bile, and fecal bile acid excretion in ethanol-exposed rats. The independent bile acid fraction showed no significant differences between both ethanol groups with respect to Na+, K+, and Cl- concentrations. CONCLUSIONS: Folic acid increases bile flow, bile acid synthesis from cholesterol, and bile acid excretion via feces, thus provoking a decrease in serum and hepatic cholesterol. However none of these actions were observed in supplemented control rats. This, therefore, could be yet another beneficial effect of folic acid on alcoholic patients.
机译：目的：胆固醇的长期摄入会改变胆固醇的代谢。在先前的文章中，我们证明了叶酸的抗氧化能力，这可能对预防乙醇引起的损害很有用。我们想确定乙醇对胆固醇和胆汁代谢的影响，以及补充叶酸的饮食是否可以改变大鼠长期摄入乙醇引起的变化。方法：我们使用了四个实验组：（1）对照组，（2）酒精，（3）补充叶酸的酒精和（4）补充叶酸的对照组。在所有实验组中，我们测量了肝脏3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶，以及血清，肝，胆汁和粪便中的胆固醇和胆汁酸。结果：我们发现用酒精喂养的组显示出较高的肝HMG-CoA还原酶活性，总肝和血清胆固醇浓度，胆汁胆固醇分泌浓度和胆固醇肠肝循环。当以酒精喂养的大鼠补充叶酸时，总血清和肝胆固醇水平降低。在两个慢性乙醇组中，肝胆汁酸浓度均升高。在乙醇暴露的大鼠中，补充叶酸可显着增加胆汁胆固醇的分泌，胆汁中的胆汁酸和粪便胆汁酸的排泄。独立的胆汁酸馏分在两个乙醇基团之间均未显示出Na +，K +和Cl-浓度的显着差异。结论：叶酸可增加胆汁流量，胆固醇中胆汁酸的合成以及通过粪便排泄胆汁酸，从而引起血清和肝胆固醇的降低。然而，在补充的对照大鼠中没有观察到这些作用。因此，这可能是叶酸对酒精中毒患者的又一有益作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号