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首页> 外文学位 >Chorionic gonadotropin patterns during early human pregnancy and an early marker for pregnancy outcome.
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Chorionic gonadotropin patterns during early human pregnancy and an early marker for pregnancy outcome.

机译：人类早期妊娠的绒毛膜促性腺激素模式和妊娠结局的早期标志物。

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摘要

Population-based studies of environmental hazards to reproduction now rely on the measurements of human chorionic gonadotropin (hCG) in daily urine samples to detect pregnancy and early pregnancy loss (EPL). The studies reported here had the following broad objectives: (1) to characterize the endocrine signals that identify early pregnancy in order to develop a broadly applicable definition of pregnancy and algorithms for assessment of EPL for field-studies when only urine samples are used and (2) to develop an early biomarker for pregnancy outcome based on the ratio of bioactivity to immunoreactivity measurements of hCG (hCG B:I ratio) in daily periimplantaion urine samples. Periimplantation profiles of hCG in the blood and urine of conceptive cycles that ended in live birth (LB), clinical abortion (CAB), and early pregnancy loss (EPL) were characterized. No significant differences were observed for the days of hCG appearance in serum or in urine, the concentrations of hCG on the day of detection or the incremental change in hCG concentration on the day of detection between pregnancy outcome groups. Additionally, a strategy is proposed in which the day of ovulation is used to establish an "implantation window" with biomarkers for ovulation, pregnancy, and the ovarian response to pregnancy. The hourly hCG secretion profiles in the periimplantation blood samples of successful pregnancies were then characterized. The amount of hCG in circulation was observed to increase in a consistent manner with no pronounced hCG pulsatility. Immunoassays to the key urinary hormonal biomarkers of reproductive function and pregnancy were next adapted to an automated assay platform and used to characterize the menstrual cycles of pregnancies resulting in LB thus demonstrating the application of automated immunoassays for hormone biomarkers to characterize complete conceptive menstrual cycles. Finally, the daily levels of immunoreactive and bioactive hCG metabolites (IhCG and BhCG) in daily periimplantation urine samples from pregnancies that resulted in LB, CAB, and EPL were characterized and compared. These data provided specific evidence that the daily patterns of BhCG metabolites could be monitored in periimplantation urine samples and that they convey specific information about pregnancy outcome not conveyed by patterns of IhCG metabolites.
机译：现在，基于人群的生殖环境危害研究依赖于每日尿液样本中绒毛膜促性腺激素（hCG）的检测，以检测妊娠和早期妊娠丢失（EPL）。此处报道的研究具有以下广泛目标：（1）表征能够识别早期妊娠的内分泌信号，以便开发出广泛适用的妊娠定义以及仅使用尿液样本进行田间研究的EPL评估算法；（ 2）根据每日植入后尿液样本中hCG的生物活性与免疫反应性的比值（hCG B：I比值），为妊娠结局开发早期的生物标志物。对特征性周期的血液和尿液中hCG的围着植入过程进行了描述，这些周期以活产（LB），临床流产（CAB）和早孕流产（EPL）结束。在怀孕结局组之间，血清或尿液中hCG出现的天数，检测日的hCG浓度或检测日的hCG浓度增量变化均无显着差异。另外，提出了一种策略，其中将排卵日用于建立具有用于排卵，妊娠和卵巢对妊娠反应的生物标志物的“植入窗”。然后，对成功妊娠的植入物周围血样中的每小时hCG分泌特征进行表征。观察到循环中hCG的量以一致的方式增加，而没有明显的hCG搏动。接下来，对生殖功能和妊娠的关键泌尿激素生物标记物的免疫测定适用于自动测定平台，并用于表征导致月经的妊娠的月经周期，从而证明了针对荷尔蒙生物标记物的自动免疫测定法在表征完整的概念性月经周期中的应用。最后，表征并比较了孕妇每天植入后尿液样本中导致LB，CAB和EPL的免疫反应性和生物活性hCG代谢物（IhCG和BhCG）的每日水平。这些数据提供了具体的证据，表明可以在植入前后的尿液样本中监测BhCG代谢物的每日模式，并且它们传达了有关IhCG代谢物模式无法传达的妊娠结局的具体信息。

著录项

  • 作者

    Lohstroh, Peter Norton.;

  • 作者单位

    University of California, Davis.;

  • 授予单位 University of California, Davis.;
  • 学科 Health Sciences Obstetrics and Gynecology.; Health Sciences Toxicology.
  • 学位 Ph.D.
  • 年度 2005
  • 页码 178 p.
  • 总页数 178
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 妇幼卫生;毒物学（毒理学）;
  • 关键词

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