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首页> 外文学位 >Quantitative three-dimensional proton magnetic resonance spectroscopy in multiple sclerosis and traumatic brain injury.
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Quantitative three-dimensional proton magnetic resonance spectroscopy in multiple sclerosis and traumatic brain injury.

机译：定量三维质子磁共振波谱在多发性硬化症和颅脑损伤中的应用。

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摘要

Background and Methods. Magnetic Resonance Spectroscopy (MRS) is the only non-invasive method for studying tissue biochemistry in vivo. In the brain, proton MRS (1H-MRS) is used to measure concentrations of four main metabolic markers: Nacetylaspartate (NAA) for neuronal integrity; choline (Cho) for membrane turnover rate; creatine (Cr) and myo-inositol (mI) for glial status. Most 1H-MRS studies, however, use either large single voxels (3.5--8 cc) that introduce partial volume effects, or 2D slices which, at best, cover only 10% of the brain. The 3D 1 H-MRS approach employed in this work provides superior resolution (0.75 cc) and coverage (360 cc, ∼30% of brain). Through various post-processing approaches we investigated localized and diffuse damage in two diseases in which disability correlates only moderately with findings on conventional MRI: multiple sclerosis (MS) and mild traumatic brain injury (mTBI). In addition, to quantify the extent to which metabolites' signals variations reflect changes in transverse (T2) relaxation time versus altered concentrations, we mapped the T2 distribution of NAA, Cr and Cho in MS patients and controls of different age groups.;Results and Conclusions. The results revealed that in early MS there is absence of tissue atrophy and apparent axonal dysfunction (NAA loss), but diffuse astrogliosis (elevated mI and Cr), as well as possible inflammation, de- and re-myelination (elevated Cho and Cr) during clinical remission and despite treatment. There was no evidence of thalamic damage in mTBI. There was a gradual (less than 1 ms/year) decrease with age of all T2s in the controls. MS patients had lower T2s, but for the purpose of metabolic quantification it is shown that an average metabolite T2 yields a precision of better than +/-10% at echo times under 100 ms in both MS patients and controls.
机译：背景和方法。磁共振波谱（MRS）是研究体内组织生物化学的唯一非侵入性方法。在大脑中，质子MRS（1H-MRS）用于测量四种主要代谢标记物的浓度：神经元完整性的NAST（天冬氨酸）；胆碱（Cho）用于膜转换率;肌酸（Cr）和肌醇（mI）用于神经胶质状态。但是，大多数1H-MRS研究使用的是会产生部分体积效应的大型单个体素（3.5--8 cc），或使用二维切片，最多只能覆盖大脑的10％。这项工作中使用的3D 1 H-MRS方法可提供出色的分辨率（0.75 cc）和覆盖范围（360 cc，约占大脑的30％）。通过各种后处理方法，我们研究了两种疾病中的局限性和弥漫性损伤，其中残疾仅与常规MRI的发现有中等相关性：多发性硬化症（MS）和轻度颅脑损伤（mTBI）。此外，为了量化代谢物信号变化反映横向（T2）弛豫时间相对于浓度变化的程度，我们绘制了MS患者和不同年龄组对照中NAA，Cr和Cho的T2分布图。结论。结果显示，在早期MS中，没有组织萎缩和明显的轴突功能障碍（NAA缺失），但弥漫性星形胶质变（mI和Cr升高）以及可能的炎症，脱髓鞘和再髓鞘化（Cho和Cr升高）在临床缓解期间并且尽管治疗。在mTBI中没有丘脑受损的证据。随着对照组中所有T2年龄的增加，逐渐减少（少于1毫秒/年）。 MS患者的T2较低，但出于代谢定量的目的，在MS患者和对照组中，在100 ms以下的回声时间，平均代谢物T2产生的精度优于+/- 10％。

著录项

  • 作者

    Kirov, Ivan I.;

  • 作者单位

    New York University.;

  • 授予单位 New York University.;
  • 学科 Biology Neuroscience.;Health Sciences Radiology.
  • 学位 Ph.D.
  • 年度 2010
  • 页码 180 p.
  • 总页数 180
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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