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首页> 外文学位 >Appetite regulation in winter flounder (Pseudopleuronectes americanus): characterization of melanin-concentrating hormone (MCH) and gonadotropin-releasing hormone (GnRH) transcript families and their role in feeding behaviour.
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Appetite regulation in winter flounder (Pseudopleuronectes americanus): characterization of melanin-concentrating hormone (MCH) and gonadotropin-releasing hormone (GnRH) transcript families and their role in feeding behaviour.

机译：冬季比目鱼（Pseudopleuronectes americanus）的食欲调节：黑色素浓缩激素（MCH）和促性腺激素释放激素（GnRH）转录本家族的特征及其在喂养行为中的作用。

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摘要

In vertebrates, appetite regulation is a complex process involving both nervous and endocrine systems. Melanin-concentrating hormone (MCH) and gonadotropin-releasing hormone (GnRH) are two endocrine factors that have been found to regulate food intake in fish and other vertebrates. These hormones were characterized in winter flounder, Pseudopleuronectes americanus, a flatfish common in Newfoundland bottom waters. mRNAs encoding several forms of both hormones were identified and shown to be expressed in tissues previously found to be involved in appetite regulation, including the brain (telencephalon, optic tectum, and hypothalamus) and midgut. Adult fish submitted to fasting displayed higher brain expression levels of transcripts encoding MCH and its receptor, MCH-R1, suggesting that the MCH system might stimulate feeding in flounder. Conversely, both chicken- and salmon-GnRH mRNA levels were lower in fasted fish suggesting an appetite-inhibiting effect. Our results suggest that MCH and GnRH, along with their receptors, might play an important role in regulating feeding in winter flounder.
机译：在脊椎动物中，食欲调节是一个复杂的过程，涉及神经系统和内分泌系统。黑色素浓缩激素（MCH）和促性腺激素释放激素（GnRH）是两个内分泌因子，已发现它们可调节鱼类和其他脊椎动物的食物摄入量。这些激素在比目鱼（Pseudopleuronectes americanus）（一种在纽芬兰底水中常见的比目鱼）中得到了表征。编码两种激素的几种形式的mRNA被鉴定出来并显示在先前发现参与食欲调节的组织中表达，包括大脑（端脑，视神经顶盖和下丘脑）和中肠。接受禁食的成年鱼显示出编码MCH及其受体MCH-R1的转录本在脑中的表达水平较高，表明MCH系统可能刺激比目鱼进食。相反，在禁食鱼中，鸡和鲑鱼的GnRH mRNA水平均较低，表明有抑制食欲的作用。我们的结果表明，MCH和GnRH及其受体可能在调节冬季比目鱼的摄食中起重要作用。

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  • 作者

    Tuziak, Sarah.;

  • 作者单位

    Memorial University of Newfoundland (Canada).;

  • 授予单位 Memorial University of Newfoundland (Canada).;
  • 学科 Biology Physiology.
  • 学位 M.Sc.
  • 年度 2011
  • 页码 165 p.
  • 总页数 165
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 普通生物学;
  • 关键词

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