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首页> 外文期刊>Peptides: An International Journal >Melanin-concentrating hormone (MCH) and gonadotropin-releasing hormones (GnRH) in Atlantic cod, Gadus morhua: Tissue distributions, early ontogeny and effects of fasting
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Melanin-concentrating hormone (MCH) and gonadotropin-releasing hormones (GnRH) in Atlantic cod, Gadus morhua: Tissue distributions, early ontogeny and effects of fasting

机译：大西洋鳕鱼中的黑色素浓缩激素（MCH）和促性腺激素释放激素（GnRH）：组织分布，早期个体发育和禁食的影响

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摘要

Melanin-concentrating hormone (MCH) is classically known for its role in regulating teleost fish skin color change for environmental adaptation. Recent evidence suggests that MCH also has appetite-stimulating properties. The gonadotropin-releasing hormone (GnRH) peptide family has dual roles in endocrine control of reproduction and energy status in fish. Atlantic cod (Gadus morhua) are a commercially important aquaculture species inhabiting the shores of Atlantic Canada. In this study, we examine MCH and GnRH transcript expression profiles during early development as well as in central and peripheral tissues and quantify juvenile Atlantic cod MCH and GnRH hypothalamic mRNA expressions following food deprivation. MCH and GnRH3 cDNAs are maternally deposited into cod eggs, while MCH has variable expression throughout early development. GnRH2 and GnRH3 mRNAs "turn-on" during mid-segmentation once the brain is fully developed. For both MCH and GnRH, highest expression appears during the exogenous feeding stages, perhaps supporting their functions as appetite regulators during early development. MCH and GnRH transcripts are found in brain regions related to appetite regulation (telencephalon/preoptic area, optic tectum/thalamus, hypothalamus), as well as the pituitary gland and the stomach, suggesting a peripheral function in food intake regulation. Atlantic cod MCH mRNA is upregulated during fasting, while GnRH2 and GnRH3 transcripts do not appear to be influenced by food deprivation. In conclusion, MCH might be involved in stimulating food intake in juvenile Atlantic cod, while GnRHs may play a more significant role in appetite regulation during early development.
机译：富含黑色素的激素（MCH）以其在调节硬骨鱼皮肤颜色变化以适应环境方面的作用而闻名。最近的证据表明，妇幼保健也具有刺激食欲的特性。促性腺激素释放激素（GnRH）肽家族在鱼类的内分泌控制生殖和能量状态中具有双重作用。大西洋鳕（Gadus morhua）是居住在加拿大大西洋沿岸的商业上重要的水产养殖物种。在这项研究中，我们检查了早期发育期间以及中部和周边组织中的MCH和GnRH转录本表达谱，并定量了食物剥夺后大西洋鳕鱼MCH和GnRH下丘脑mRNA的表达。 MCH和GnRH3 cDNA母本沉积在鳕鱼卵中，而MCH在整个早期发育过程中具有可变表达。一旦大脑完全发育，GnRH2和GnRH3 mRNA就会在节段中期“开启”。对于MCH和GnRH，在外源性饲喂阶段出现最高的表达，这可能支持它们在早期发育中作为食欲调节剂的功能。在与食欲调节有关的大脑区域（脑/前视区，视神经顶盖/丘脑，下丘脑）以及脑垂体和胃中发现MCH和GnRH转录物，提示其在食物摄入调节中具有外围功能。禁食期间大西洋鳕鱼MCH mRNA上调，而GnRH2和GnRH3转录本似乎不受食物匮乏的影响。总之，MCH可能参与刺激大西洋大西洋鳕鱼的食物摄入，而GnRHs在早期发育过程中可能在食欲调节中起更重要的作用。

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