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首页> 外文学位 >Occupational exposure to crystalline silica and the development of systemic lupus erythematosus (SLE): A case-control study in the southeastern United States.
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Occupational exposure to crystalline silica and the development of systemic lupus erythematosus (SLE): A case-control study in the southeastern United States.

机译：职业接触结晶二氧化硅和系统性红斑狼疮（SLE）的发展：美国东南部的病例对照研究。

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Recent occupational studies link crystalline silica dust exposure to systemic lupus erythematosus (SLE). This study examines the association between silica exposure and SLE using data from a population-based case-control study of SLE in North Carolina and South Carolina. Cases were identified through community-based and university rheumatologists. Eligibility required fulfillment of the 1997 revised-American College of Rheumatology classification criteria for SLE and diagnosis between January 1, 1995 and July 30, 1999. Controls were identified through driver's license records and frequency matched to cases by age, sex, and state. The final sample consisted of 265 (93% of referred and eligible) cases and 355 (75% of screened and eligible) controls. Ninety-percent of the cases were women, 60% were African-American, and the median age at diagnosis was 39 years. In-person interviews collected a detailed lifetime job and farming history, and information on specific jobs and tasks with possible silica exposure. Follow-up telephone interviews collected additional data on potential high or medium-level silica exposure. I observed an association between SLE and silica for exposure from trades (odds ratio, OR = 3.1, 95% CI 1.4–7.0), farming (OR = 3.0, 95% CI 1.1–8.2), and trades and farming combined (medium exposure OR = 2.0, 95% CI 1.1–3.7; high exposure OR = 4.2, 95% CI 1.2–13.9). The association was seen in men and women, whites and blacks, and different education levels. As the first population-based study of silica and SLE, these results extend the literature on occupational silica exposure and SLE. The study also contributes to methods in exposure assessment through developing a protocol to retrospectively assess silica exposure from farm work.
机译：最近的职业研究将结晶二氧化硅粉尘暴露与系统性红斑狼疮（SLE）联系起来。这项研究使用来自北卡罗莱纳州和南卡罗来纳州SLE的基于人群的病例对照研究数据，研究了二氧化硅暴露与SLE之间的关联。通过社区和大学的风湿病学家确定病例。要符合资格，必须在1995年1月1日至1999年7月30日期间，符合1997年修订的美国风湿病学会对SLE和诊断的分类标准。通过驾驶执照记录和年龄，性别和州所匹配的频率来识别控件。最终样本包括265个病例（占转诊和合格病例的93％）和355个病例（经筛查和合格病例的75％）。 90％的病例是女性，60％是非裔美国人，诊断时的中位年龄为39岁。面对面采访收集了详细的终生工作和耕种历史，以及有关可能暴露于二氧化硅的特定工作和任务的信息。后续电话采访收集了有关潜在的高或中等二氧化硅暴露量的其他数据。我观察到SLE和二氧化硅之间的关联来自贸易（赔率，OR = 3.1，95％CI 1.4-7.0），农业（OR = 3.0，95％CI 1.1-8.2），以及贸易和农业相结合（中等暴露） OR = 2.0，95％CI 1.1–3.7；高暴露OR = 4.2，95％CI 1.2-13.9）。在男女，白人和黑人以及不同的教育水平中都可以看到这种联系。作为第一个基于人群的二氧化硅和SLE研究，这些结果扩展了关于职业性二氧化硅暴露和SLE的文献。该研究还通过制定一项协议来回顾性评估农场工作中的二氧化硅暴露，为暴露评估的方法做出了贡献。

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