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首页> 外文学位 >Transcriptional activity of sex chromosomes in the oocytes of the B6.Y(TIR) sex-reversed female mouse.
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Transcriptional activity of sex chromosomes in the oocytes of the B6.Y(TIR) sex-reversed female mouse.

机译：B6.Y（TIR）性逆转雌性小鼠的卵母细胞中性染色体的转录活性。

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摘要

In the B6.YTIR mouse strain, half of the XY progeny develop bilateral ovaries and the female phenotype. These XY females are infertile mainly due to the death of their embryos. This developmental failure has been attributed to a defect intrinsic to the XY oocyte.;The present study examined the transcriptional activity of the X and Y chromosomes in these oocytes. RT-PCR results show that the Ube1y gene is transcribed in the XY ovary at all stages examined and also in growing XY oocytes. The Sry gene was transcribed only at the onset of ovarian differentiation whereas the Zfy gene was undetectable at all stages during fetal life. The Xist gene, which is involved in X inactivation, was not expressed in XY oocytes. We speculate that expression of Y-encoded genes may have a deleterious effect on the quality of the oocytes and thus renders them incompetent for post-fertilization development.
机译：在B6.YTIR小鼠品系中，一半的XY后代发育成双侧卵巢和雌性表型。这些XY雌性不孕，主要是因为它们的胚胎死亡。这种发育失败归因于XY卵母细胞固有的缺陷。本研究检查了这些卵母细胞中X和Y染色体的转录活性。 RT-PCR结果表明，在所有检查的阶段中，Ube1y基因都在XY卵巢中以及在生长的XY卵母细胞中转录。 Sry基因仅在卵巢分化开始时才转录，而Zfy基因在胎儿生命中的所有阶段均未检测到。 X灭活中涉及的Xist基因未在XY卵母细胞中表达。我们推测，Y编码基因的表达可能对卵母细胞的质量产生有害影响，从而使它们不适合受精后发育。

著录项

  • 作者

    Nasseri, Roksana.;

  • 作者单位

    McGill University (Canada).;

  • 授予单位 McGill University (Canada).;
  • 学科 Health Sciences Obstetrics and Gynecology.;Biology Molecular.;Biology Genetics.
  • 学位 M.Sc.
  • 年度 1999
  • 页码 85 p.
  • 总页数 85
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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