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首页> 外文学位 >The integrative relationship between insulin and insulin-like growth factor 1-induced cardiovascular responses and sympathetic nervous responses.
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The integrative relationship between insulin and insulin-like growth factor 1-induced cardiovascular responses and sympathetic nervous responses.

机译：胰岛素和胰岛素样生长因子1诱导的心血管反应和交感神经反应之间的整合关系。

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摘要

Insulin and insulin-like growth factor 1 (IGF-1) share some structure homologies and exert similar metabolic as well as cardiovascular actions. Insulin and IGF-1 have been demonstrated to decrease cardiovascular tone and increase blood flows in skeletal muscle. Insulin has also been showed to increase sympathetic nerve activity that may play a role in the regulation of cardiovascular dynamics. This study investigated the effects of insulin and IGF-1 on cardiovascular parameters and sympathetic nerve activity and the correlation between them. We also evaluated the role of baroreflex, plasma glucose level and regional sympathectomy in those insulin and IGF-1 induced responses. Normal wistar rats were anesthetized with chloralose/urethane. The femoral artery and vein were cannulated to monitor mean arterial pressure (MAP) and heart rate (HR) or for infusion or blood sampling. The lumbar sympathetic nerve or renal sympathetic nerve was isolated and placed on electrodes for nerve activity recording. Electromagnetic flow probes were placed around the iliac arteries for blood flow measurement. The systemic administration of insulin and IGF-1 resulted in significant decrease in MAP. Insulin increased lumbar sympathetic nerve activity (LSNA) independent of the prevailing glucose concentration and baroreflex. It increased renal sympathetic nerve activity (RSNA) only under hypoglycemia condition. IGF-1 decreased both LSNA and RSNA, but this effect was modulated by glycemic status. Lumbar sympathectomy caused greater increase in skeletal muscle blood flow in response to both insulin and IGF-1 when hypoglycemia occurred. But when hypoglycemia was prevented, IGF-1 induced increase in blood flow was suppressed in sympathetic denervated iliac artery. We concluded that insulin and IGF-1 have both similar and distinct effects on cardiovascular system and sympathetic nervous system. They both may act directly on vasculature to elicit vasodilation thus decrease MAP Insulin can selectively increase sympathetic nerve activity, while IGF-1 decreases sympathetic nerve activity. These processes are modulated by glycemic status. Baroreflex may be involved but is not responsible for them.
机译：胰岛素和类胰岛素生长因子1（IGF-1）具有一些结构同源性，并具有相似的代谢和心血管作用。胰岛素和IGF-1已被证明可降低心血管张力并增加骨骼肌中的血流量。胰岛素还被证明可以增加交感神经活动，这可能在调节心血管动力学中发挥作用。这项研究调查了胰岛素和IGF-1对心血管参数和交感神经活动的影响及其之间的相关性。我们还评估了压力反射，血糖水平和局部交感神经切除在那些胰岛素和IGF-1诱导的反应中的作用。正常wistar大鼠用氯醛/氨基甲酸乙酯麻醉。插入股动脉和静脉以监测平均动脉压（MAP）和心率（HR）或进行输液或血液采样。分离腰交感神经或肾交感神经并将其放在电极上以记录神经活动。将电磁流量探针放置在the动脉周围，以进行血流量测量。胰岛素和IGF-1的全身给药导致MAP显着降低。胰岛素增加腰椎交感神经活动（LSNA），与现行的葡萄糖浓度和压力反射无关。仅在低血糖情况下才增加肾脏交感神经活性（RSNA）。 IGF-1降低了LSNA和RSNA，但这种作用受到血糖状态的调节。发生低血糖时，腰椎交感神经切除术引起对胰岛素和IGF-1的骨骼肌血流量的更大增加。但是，当预防低血糖症时，交感神经支配的动脉的IGF-1诱导的血流量增加被抑制。我们得出的结论是，胰岛素和IGF-1对心血管系统和交感神经系统具有相似和不同的作用。它们都可能直接作用于脉管系统以引起血管舒张，因此降低MAP胰岛素可以选择性地增加交感神经的活动，而IGF-1降低交感神经的活动。这些过程受血糖状态的调节。 Baroreflex可能参与其中，但对此不承担任何责任。

著录项

  • 作者

    Duanmu, Zhengbo.;

  • 作者单位

    Wayne State University.;

  • 授予单位 Wayne State University.;
  • 学科 Animal Physiology.
  • 学位 Ph.D.
  • 年度 1998
  • 页码 113 p.
  • 总页数 113
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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