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首页> 外文学位 >Diffuse photon transport in tissue-like media: Resolution limit for near-infrared imaging and an instrument for clinical spectroscopy of tissues.
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Diffuse photon transport in tissue-like media: Resolution limit for near-infrared imaging and an instrument for clinical spectroscopy of tissues.

机译：像组织一样的介质中的扩散光子传输：近红外成像的分辨率极限和用于组织临床光谱学的仪器。

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摘要

In this work I present the model for diffusive photon transport in tissue-like media along with solutions for a point source in infinite and semi-infinite media. Based on these solutions and experimental measurements, I consider the ultimate resolution of near-infrared based imaging of tissues using a simple model to describe resolution. I conclude that for a 5 cm thick tissue, the closest two objects buried in the center can be, and still be resolved is roughly 1.5 centimeters. I also show that light applied to the surface of a tissue-like medium, and detected on the same surface some distance away, penetrates into the medium. The depth of penetration is on the order of centimeters depending on the transport properties of the medium and source-detector separation. Since this light penetrates into tissue, and there is a model which describes how the transport of light through tissues depends on the tissue optical properties with sufficient accuracy, non-invasive tissue spectroscopy in the near-infrared is possible. During my thesis work a functioning tissue spectrometer was developed to demonstrate this point. I conclude by discussing measurements I made with this spectrometer on both laboratory samples and live patients. My experiments with the tissue spectrometer were instrumental in both demonstrating its capabilities and understanding advances to be made in the next generation of the device.
机译：在这项工作中，我介绍了在组织状介质中扩散光子传输的模型，以及在无限和半无限介质中的点源解。基于这些解决方案和实验测量结果，我考虑了使用简单模型描述分辨率的基于近红外组织成像的最终分辨率。我得出的结论是，对于一个5厘米厚的组织，埋在中心的最近两个物体可以并且仍然可以解决大约1.5厘米。我还表明，施加到组织状介质表面并在相距一定距离的同一表面上检测到的光会穿透介质。渗透的深度约为厘米，具体取决于介质的传输特性和源-检测器分离。由于该光穿透到组织中，并且存在一个模型来描述光通过组织的传输如何以足够的精度取决于组织的光学特性，因此近红外的非侵入性组织光谱学是可能的。在我的论文工作期间，开发了一种功能正常的组织光谱仪以证明这一点。最后，我们讨论了使用该光谱仪对实验室样本和活体患者进行的测量。我用组织光谱仪进行的实验在证明其功能和了解下一代设备的发展方面都发挥了作用。

著录项

  • 作者

    Maier, John Stewart.;

  • 作者单位

    University of Illinois at Urbana-Champaign.;

  • 授予单位 University of Illinois at Urbana-Champaign.;
  • 学科 Physics Radiation.; Physics Optics.; Physics General.
  • 学位 Ph.D.
  • 年度 1998
  • 页码 92 p.
  • 总页数 92
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 原子核物理学、高能物理学;光学;物理学;
  • 关键词

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