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Preclinical assessment of the multi-YAG laser for intracorporeal lithotripsy of human urinary calculi.

机译：多YAG激光对人尿结石的体内碎石术的临床前评估。

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The dual wavelength Nd:YAG (multi-YAG) laser is a multi-purpose surgical laser designed to emit 1440 nm light in the pulsed mode for ablation of tissue. A three-part experimental study was undertaken to define the optimal parameters for laser lithotripsy and also to investigate the safety of this laser for fragmenting ureteral calculi.; Urinary calculi were first ablated in an in vitro study (n = 120). Lithotripsy was then performed in an ex vivo pig model (n = 45) and in nine female swine in order to study the acute and chronic tissue effects of treatment.; Fragmentation efficacy was significantly affected by the pulse energy (p {dollar}<{dollar} 0.001). The most efficacious and rapid fragmentation occurred at energies between 0.6 J and 0.9 J/pulse. Ex vivo lithotripsy caused low grade acute tissue effects in 37/42 cases and moderate to high grade injury in five ureters. There were no chronic high grade injuries in the in vivo model. These results suggest that the multi-YAG laser can efficiently ablate urinary stones with acceptable levels of acute and chronic tissue injury.

机译：双波长Nd：YAG（multi-YAG）激光器是一种多用途外科手术激光器，旨在以脉冲模式发射1440 nm的光，用于消融组织。进行了一个由三部分组成的实验研究，以确定激光碎石术的最佳参数，并研究该激光碎裂输尿管结石的安全性。在一项体外研究中首先消融了尿路结石（n = 120）。然后在离体猪模型（n = 45）和九只雌性猪中进行碎石术，以研究治疗的急性和慢性组织效应。碎裂功效受脉冲能量的显着影响（p {dollar} <{dollar} 0.001）。最有效和最迅速的破碎发生在0.6 J和0.9 J /脉冲之间的能量上。离体碎石术在37/42例病例中引起低度急性组织效应，在5个输尿管中引起中度至高度损伤。在体内模型中没有慢性高等级损伤。这些结果表明，多YAG激光可以有效消融尿结石，并具有可接受的急性和慢性组织损伤水平。

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作者
Wollin, Timothy Armin.;
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作者单位

University of Alberta (Canada).;

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授予单位 University of Alberta (Canada).;
学科 Biophysics Medical.; Health Sciences Medicine and Surgery.
学位 M.Sc.
年度 1996
页码 166 p.
总页数 166
原文格式 PDF
正文语种 eng
中图分类生物物理学;
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专利

1. Treatment outcomes of semirigid ureterorenoscopy and intracorporeal lithotripsy in pregnant women with obstructive ureteral calculi. [J] . Polat F, Yesil S, Kirac M, Urological research . 2011,第6期

机译：输尿管结石梗阻孕妇的半刚性输尿管镜检查和体内碎石术治疗结果。
2. Cost-effectiveness and efficiency of shockwave lithotripsy vs flexible ureteroscopic holmium:yttrium-aluminium-garnet laser lithotripsy in the treatment of lower pole renal calculi. [J] . Koo V, Young M, Thompson T, BJU international . 2011,第11期

机译：冲击波碎石术与柔性输尿管镜：钇铝石榴石激光碎石术治疗下极肾结石的成本效益和效率。
3. Pneumatic lithotripsy versus laser lithotripsy in the endoscopic treatment of ureteral calculi. [J] . Sun Y, Wang L, Liao G, Journal of endourology . 2001,第6期

机译：气压弹道碎石术与激光碎石术在输尿管结石内镜治疗中的比较。
4. Intracorporeal lithotripsy with the holmium:YAG laser [C] . John D. Denstedt, Univ. of Western Ontario, London, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V . 1995

机译：Y：YAG激光进行体内碎石术
5. The Study of Special Urogynecologic Topics Related to the Pelvic Floor and Lower Urinary Tract: A Focus on Recurrent Urinary Tract Infections Between Two Cohorts of Women & the Assessment of Women's Reluctance to Use Topical Vaginal Estrogen [D] . Dune, Tanaka Junior. 2019

机译：关于盆腔楼层和低尿路相关的特殊辅音学主题研究：对妇女两组队队之间的复发性尿路感染的关注，妇女不愿意使用局部阴道雌激素的评估
6. Laser lithotripsy in the treatment of ureteral calculi. [O] . K E Psihramis, M B Buckspan 1990

机译：激光碎石术治疗输尿管结石。
7. Clinical application of EDAP LT-01 in extracorporeal shock wave lithotripsy for upper urinary tract calculi. [O] . 中村剛, 木藤宏樹, 池田良一, 1999

机译：EDAP LT-01在体外冲击波碎石术治疗上尿路结石中的临床应用。
8. Modeling of Laser Ablation and Fragmentation of Human Calculi. [R] . Gitomer, S., Jones, R. D., Howsare, C. 1989

机译：人体结石的激光烧蚀和破碎模型。

Preclinical assessment of the multi-YAG laser for intracorporeal lithotripsy of human urinary calculi.

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