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首页> 外文学位 >Interaction between somatotropin, insulin-like growth factor I, insulin-like growth factor binding proteins and reproduction in female beef cattle
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Interaction between somatotropin, insulin-like growth factor I, insulin-like growth factor binding proteins and reproduction in female beef cattle

机译：生长激素，胰岛素样生长因子I，胰岛素样生长因子结合蛋白与雌性肉牛繁殖之间的相互作用

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摘要

Female beef cattle actively immunized against growth hormone releasing factor (GRF) were used in three experiments to investigate the relationship between somatotropin (ST), insulin-like growth factor-I (IGF-I), insulin-like growth factor binding proteins (IGFBP) and reproduction function. In the first study, prepubertal Angus, Charolais, and Simmental heifers that were actively immunized against GRF or restricted in feed intake exhibited decreased body weight and serum concentration of IGF-I. Attainment of puberty was delayed by GRF-immunization in Angus and Charolais, but not in Simmental heifers. Restriction of feed intake did not affect reproductive performance in Angus, Charolais or Simmental heifers.;In the second study, replacement therapy with recombinantly derived bovine somatotropin (rbST) was administered to initiate puberty in two groups of prepubertal, GRF-immunized Angus and Charolais heifers for 56 d. Daily injections of rbST increased serum ST, IGF-I, insulin, and plasma glucose; however, decreased serum IGFBP-2. During the 56-d treatment period heifers initiated puberty at similar rates, regardless of rbST treatment.;To clarify interactions of ST, IGF-I, IGFBP and follicular development we administered rbST and (or) pregnant mare serum gonadotropin (PMSG) to cyclic, normal- and GRF-immunized beef cows in the third study. Estrous cycles were synchronized with prostaglandin (PGF$sb{rm 2a})$ and treatment administration (rbST, PMSG, rbST + PMSG, or vehicle) occurred at 0 and 24 h following last PGF$sb{rm 2a}.$ Serum, ovary bearing largest follicle (DOM), and follicular fluid (FFL) from the DOM and second largest follicle (SUB) were collected 40 h after PGF$sb{rm 2a}.$ Administration of PMSG had no effect on any parameter examined; therefore, data were combined and two treatments resulted (rbST and vehicle). Immunization against GRF decreased serum and FFL concentrations of IGF-I and increased concentrations of IGFBP-2 in serum and FFL from SUB, but not DOM. Treatment with rbST increased serum and FFL IGF-I, and increased both serum and FFL IGFBP-2 (both DOM and SUB).
机译：在三个实验中，对生长激素释放因子（GRF）进行了主动免疫的雌性肉牛用于研究生长激素（ST），胰岛素样生长因子-I（IGF-1）和胰岛素样生长因子结合蛋白（IGFBP）之间的关系）和复制功能。在第一项研究中，已针对GRF进行了主动免疫或限制了采食量的青春期前安格斯，夏洛来牛和西门塔尔小母牛表现出体重降低和IGF-I血清浓度降低。在安格斯和夏洛来牛中进行GRF免疫可延缓青春期的获得，但西门塔尔牛的幼体则不会。限制采食量不影响安格斯，夏洛来牛或西门塔尔牛的生殖性能。在第二项研究中，采用重组来源的牛生长激素（rbST）替代疗法在两组青春期前开始青春期，这是经GRF免疫的安格斯和夏洛来牛。小母牛56 d。每天注射rbST会增加血清ST，IGF-I，胰岛素和血浆葡萄糖。但是，血清IGFBP-2降低。在56天的治疗期间，无论采用rbST治疗如何，小母牛的青春期均以相似的速率开始。为了阐明ST，IGF-I，IGFBP和卵泡发育的相互作用，我们将rbST和/或妊娠母马血清促性腺激素（PMSG）给予了循环在第三项研究中，分别接种了普通和GRF免疫的肉牛。发情周期与前列腺素（PGF $ sb {rm 2a}）$同步，最后一次PGF $ sb {rm 2a}后0和24小时进行治疗管理（rbST，PMSG，rbST + PMSG或赋形剂）。在PGF $ sb {rm 2a}后40 h，从最大卵泡（DOM）的卵巢中收集卵，从DOM和第二大卵泡（SUB）收集卵泡液（FFL）。因此，将数据合并并得到两种处理（rbST和媒介物）。免疫GRF可降低SUB血清和FFL的血清和FFL的血清和FFL浓度，增加IGFBP-2的浓度，但不能降低DOM。 rbST治疗可增加血清和FFL IGF-I，并增加血清和FFL IGFBP-2（DOM和SUB）。

著录项

  • 作者

    Stanko, Randy Louis.;

  • 作者单位

    North Carolina State University.;

  • 授予单位 North Carolina State University.;
  • 学科 Animal sciences.;Animal Physiology.
  • 学位 Ph.D.
  • 年度 1993
  • 页码 244 p.
  • 总页数 244
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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