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Tomosynthesis-based intraoperative dosimetry for low dose rate prostate brachytherapy.

机译:基于断层合成的术中剂量低剂量率前列腺近距离放射治疗。

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摘要

The aim of this study is to develop an intraoperative dose assessment procedure that can be performed after an I-125 prostate seed implantation, while the patient is still under anaesthesia. To accomplish this, we reconstruct the 3D position of each seed and co-register it with the prostate contour acquired with a transrectal ultrasound (TRUS) probe. Our seed detection method involves a tomosynthesis-based filtered reconstruction of the volume of interest requiring 7 projections acquired over an angle of 60° with an isocentric imaging system. The co-registration between the tomosynthesis-based seed positions and the TRUS-based prostate contour is based on the planned position. A phantom and a clinical study (25 patients) were carried out to validate the technique. In the patient study, the automatic tomosynthesis-based reconstruction yields a seed detection rate of 96.7% and less than 2.6% false-positive. The seed localization error obtained with a phantom study is 0.4 +/- 0.4 mm. The co-registration method based on planned seed position has proved to be not accurate enough for dosimetric purposes. We believe that this technique may be used to discover considerable underdosage and to improve the dosimetric coverage by potentially reimplanting additional seeds.
机译:这项研究的目的是开发一种术中剂量评估程序,该程序可在I-125前列腺种子植入后仍在麻醉状态下执行。为此,我们重建每个种子的3D位置,并将其与通过经直肠超声(TRUS)探头获得的前列腺轮廓共配准。我们的种子检测方法包括基于层析合成的目标体积的滤波重建,需要使用等心成像系统在60°的角度上获取7个投影。基于断层合成的种子位置和基于TRUS的前列腺轮廓之间的共配准基于计划的位置。进行了幻像和临床研究(25例患者)以验证该技术。在患者研究中,基于断层合成的自动重建产生的种子检出率为96.7%,假阳性率低于2.6%。通过幻像研究获得的种子定位误差为0.4 +/- 0.4毫米。事实证明,基于计划种子位置的共注册方法不够精确,无法达到剂量学目的。我们认为,该技术可用于发现相当大的剂量不足,并通过潜在地再植入其他种子来提高剂量覆盖率。

著录项

  • 作者

    Brunet-Benkhoucha, Malik.;

  • 作者单位

    McGill University (Canada).;

  • 授予单位 McGill University (Canada).;
  • 学科 Health Sciences Radiology.;Health Sciences Oncology.;Health Sciences Human Development.
  • 学位 M.Sc.
  • 年度 2009
  • 页码 95 p.
  • 总页数 95
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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