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Evaluation of Select Food Additive Exposures in Children with Crohn's Disease.

机译：克罗恩氏病患儿选择食品添加剂暴露的评估。

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摘要

Crohn's Disease (CD) is a chronic, debilitating inflammatory bowel disease and recent research has revealed the possibility that environmental exposures such as diet may play a role in CD etiology and disease activity. Several food additives (e.g. carboxymethylcellulose, carrageenan, maltodextrin) have been shown to cause intestinal inflammation, mucosal barrier alterations, and microbiome dysbiosis in animal models, therefore it has been hypothesized that these additives may be associated with disease activity in children with CD. This project evaluated food additive exposure in children with CD in an effort to understand additive intake among this population and to establish a methodology for future studies. A cohort of 135 children (ages 8-21) enrolled in a Philadelphia Children's Hospital trial evaluating bone health completed 24-hour dietary recalls at baseline, 6, 12, and 24 months. All recorded foods from the baseline visit were compiled into a database and organized into 31 distinct food groupings, and 4,965 unique foods were examined for the presence of soy lecithin, carboxymethylcellulose, xanthan gum, maltodextrin, titanium dioxide, carrageenan, aluminosilicates, and polysorbate-80 by evaluating ingredient labels. The additives with the highest number of mean exposures per day were soy lecithin (2.71 +/- 1.34), xanthan gum (0.96 +/- 0.72), maltodextrin (0.95 +/- 0.77), and carrageenan (0.58 +/- 0.63). The foods with the fewest mean exposures per day included titanium dioxide (0.09 +/- 0.21), polysorbate-80 (0.07 +/- 0.16) and carboxymethylcellulose (0.05 +/- 0.13), while no exposures to aluminosilicates were found. Of the eight additives of interest, participants were exposed to an average of 2.7 different additives per recall day and experienced an average of 5.4 total additive exposures per recall day. In evaluating the 24-hour dietary recall results, grouping foods, and determining food additive content, unique recommendations were created for future studies assessing food additive exposure and the relationship to CD disease activity, including more precise 24-hour recall intake and utilizing available ingredient databases.
机译：克罗恩病（CD）是一种慢性衰弱性炎症性肠病，最近的研究表明，饮食等环境暴露可能会在CD病因和疾病活动中发挥作用。在动物模型中，几种食品添加剂（例如羧甲基纤维素，角叉菜胶，麦芽糊精）已显示会引起肠道炎症，粘膜屏障改变和微生物组功能异常，因此，据推测这些添加剂可能与CD儿童患病有关。该项目评估了患有CD的儿童的食品添加剂暴露量，以了解该人群中添加剂的摄入量，并为今后的研究建立方法。费城儿童医院的一项评估骨骼健康的135名儿童（8-21岁）在基线期，第6、12和24个月完成了24小时的膳食召回。从基线访视开始，所有记录的食物均被汇编到数据库中，并分为31个不同的食物类别，并且检查了4,965种独特食物中是否存在大豆卵磷脂，羧甲基纤维素，黄原胶，麦芽糊精，二氧化钛，角叉菜胶，硅铝酸盐和聚山梨酯。 80通过评估成分标签。每天平均接触次数最多的添加剂是大豆卵磷脂（2.71 +/- 1.34），黄原胶（0.96 +/- 0.72），麦芽糊精（0.95 +/- 0.77）和角叉菜胶（0.58 +/- 0.63） 。每天平均暴露量最少的食物包括二氧化钛（0.09 +/- 0.21），聚山梨酯80（0.07 +/- 0.16）和羧甲基纤维素（0.05 +/- 0.13），而未发现铝硅酸盐的暴露。在感兴趣的八种添加剂中，参与者每个召回日平均接触2.7种不同的添加剂，每个召回日平均接触5.4次总添加剂。在评估24小时饮食召回结果，对食物进行分组并确定食物添加剂的含量时，针对未来研究创建了独特的建议，以评估食物添加剂的暴露量以及与CD疾病活动的关系，包括更精确的24小时召回摄入量和利用现有成分数据库。

著录项

  • 作者

    Swan, C. Kaiulani.;

  • 作者单位

    University of Washington.;

  • 授予单位 University of Washington.;
  • 学科 Nutrition.
  • 学位 Masters
  • 年度 2016
  • 页码 34 p.
  • 总页数 34
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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