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首页> 外文学位 >AN EPIDEMIOLOGIC CASE-CONTROL ANALYSIS OF CHILDHOOD INTRACRANIAL AND SPINAL CORD TUMORS IN RELATION TO PATERNAL OCCUPATION AT BIRTH (BRAIN, CANCER).
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AN EPIDEMIOLOGIC CASE-CONTROL ANALYSIS OF CHILDHOOD INTRACRANIAL AND SPINAL CORD TUMORS IN RELATION TO PATERNAL OCCUPATION AT BIRTH (BRAIN, CANCER).

机译：与出生时（大脑，癌症）的儿童职业相关的儿童颅内和脊髓肿瘤的流行病学病例对照分析。

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摘要

Epidemiologic case-control studies of small groups of childhood nervous system tumor patients have suggested that parental employment in occupations with exposure to hydrocarbons is a risk factor for disease. The main focus of this case-control study was to assess the paternal occupation at the time of birth of offspring who later developed childhood intracranial and spinal tumors. All children under 15 years of age dying of such tumors in Texas, during the period 1964-1980, were selected as cases. Disease and demographic data were abstracted from death certificates. The birth certificate for each child of the final group of 499 cases was located and parental occupation information, as well as demographic and obstetric data, were collected. The comparison group consisted of a random sample from all Texas live births with the same birth year, race and sex distribution as the cases.;Odds ratios were calculated for specific occupations and industries previously implicated as risk factors. Significantly associated odds ratios (OR) were detected for electricians (OR = 3.5), especially those working for construction companies (OR = 10.0), for employment in the printing occupations (OR = 4.5), particularly graphic arts workers (OR = 21.9), and in the electronics and electronic machinery industries (OR = 3.5). Analysis of the petroleum refining and chemical industries, which were not found in previous study populations, revealed significantly elevated odds ratios of 3.0 for occupations with probable heavy exposure to chemicals and petroleum compounds and 10.0 for salesmen of chemical products.;The paternal occupations were categorized into broad classifications of those involving hydrocarbon exposure versus those that did not, based on the occupation criteria used in the previous studies. Odds ratios did not indicate any increased risk associated with general paternal hydrocarbon exposure in the workplace. In prior studies, increased risk estimates were detected with narrower groups of occupations involving exposure to hydrocarbon materials. The data from this study were classified according to these groups, and again, no increased risks were indicated except for a statistically insignificant but elevated odds ratio for fathers who were paper and pulp mill workers.
机译：对少数儿童神经系统肿瘤患者的流行病学病例对照研究表明，在接触碳氢化合物的职业中父母工作是疾病的危险因素。这项病例对照研究的主要重点是评估后代患儿的颅骨和脊柱肿瘤。选择了1964-1980年期间德克萨斯州所有15岁以下死于此类肿瘤的儿童作为病例。疾病和人口统计学数据摘自死亡证明。找到了最后一组499例病例的每个孩子的出生证明，并收集了父母的职业信息以及人口统计和产科数据。对照组由来自德克萨斯州所有活产婴儿的随机样本组成，这些出生婴儿的出生年份，种族和性别分布与病例相同。以前针对涉及危险因素的特定职业和行业计算的赔率。在印刷行业（OR = 4.5），特别是图形艺术工作者（OR = 21.9）中，发现电工（OR = 3.5），尤其是建筑公司（OR = 10.0）的显着相关的优势比（OR）。 ，以及电子和电子机械行业（OR = 3.5）。对以前研究人群中未发现的石油精炼和化学工业的分析表明，可能大量接触化学品和石油化合物的职业的赔率比显着提高，为3.0;对于化学产品销售人员的赔率比为10.0。根据先前研究中使用的职业标准，将涉及碳氢化合物暴露的人群与不涉及碳氢化合物暴露的人群进行广泛分类。几率未表明与工作场所中一般父亲接触碳氢化合物有关的风险增加。在先前的研究中，在涉及碳氢化合物材料的较窄职业类别中发现了更高的风险估计。这项研究的数据根据​​这些组进行了分类，并且再次指出，除了统计学上无关紧要的，但造纸和制浆厂工人父亲的比值比升高外，没有增加任何风险。

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  • 作者

    JOHNSON, CHRISTINE DIANE COLE.;

  • 作者单位

    The University of Texas School of Public Health.;

  • 授予单位 The University of Texas School of Public Health.;
  • 学科 Health Sciences Public Health.
  • 学位 Ph.D.
  • 年度 1985
  • 页码 263 p.
  • 总页数 263
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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