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ANDROGEN-INHIBITION OF TONIC FOLLICLE-STIMULATING HORMONE SECRETION IN THE HAMSTER: A SEXUALLY DIFFERENTIATED TRAIT

机译：仓鼠雄激素抑制性激素刺激性激素分泌的研究：性状特征

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摘要

Experiments were conducted to investigate whether androgen-inhibition of tonic follicle-stimulating hormone (FSH) secretion in the hamster, Mesocricetus auratus, undergoes sexual differentiation during early postnatal life. Physiological concentrations of serum testosterone (T) (2.8 (+OR-) 0.3 ng/ml) inhibited 66-75% of the serum FSH response and 100% of the LH response to orchidectomy. Higher levels of serum T (> 4.7 (+OR-) 0.5 ng/ml) suppressed serum FSH below the physiological range (229 (+OR-) 18 ng/ml). Equivalent serum T concentrations prevented the serum LH response to ovariectomy, but serum FSH levels were only partially (30%) suppressed and remained greater than 500 ng/ml regardless of circulating titers of T. Males showed parallel suppression of serum and pituitary FSH in response to T; whereas, females exhibited elevated pituitary FSH as serum T and FSH levels increased.;Orchidectomy at birth (day-0) resulted in reduced sensitivity to T-inhibition of FSH secretion during adulthood. Testosterone propionate (TP) injected on days 0 and 1 prevented this desensitization in neonatally orchidectomized males, and rendered females more sensitive to T-inhibition of tonic FSH secretion during adulthood. Estradiol benzoate (EB) injected on days 0 and 1 did not influence tonic FSH responses to T during adulthood, although these females were anovulatory and had masculinized genitalia.;In adult hamsters, estradiol-17(beta) (E(,2)) and 5(alpha)-dihydrotestosterone (DHT) prevented serum FSH responses to orchidectomy. E(,2) prevented the serum FSH response to ovariectomy, but DHT was ineffective in this regard. Neonatal orchidectomy rendered adults unresponsive to DHT-inhibition of FSH secretion. Neonatal TP-treatment caused 2 of 7 females to respond to DHT-inhibition of tonic FSH secretion during adulthood.;These findings suggest that (a) partial inhibition of tonic FSH secretion in T-treated females results from estrogenic metabolities of T, (b) the capacity for androgenic (i.e. DHT) inhibition of tonic FSH secretion develops as a result of testicular androgen action during early postnatal life, and (c) this early organizational action of androgen is not mediated by aromatization to E(,2). Thus, mechanisms that mediate androgen-inhibition of tonic FSH release undergo sexual differentiation during neonatal development.
机译：进行实验以调查仓鼠Mesocricetus auratus仓鼠中滋补卵泡刺激激素（FSH）分泌的雄激素抑制在产后早期是否发生性别分化。血清睾酮（T）的生理浓度（2.8（+ OR-）0.3 ng / ml）抑制了对兰花切除术的血清FSH反应的66-75％和LH反应的100％。较高的血清T水平（> 4.7（+ OR-）0.5 ng / ml）将血清FSH抑制在生理范围（229（+ OR-）18 ng / ml）以下。等效的血清T浓度阻止了血清LH对卵巢切除术的反应，但血清FSH水平仅被部分抑制（30％），并且不管T的循环滴度如何都保持大于500 ng / ml。男性表现出血清和垂体FSH的平行抑制到T;随着出生时（第0天）的睾丸切除术导致成年期对T抑制FSH分泌的敏感性降低，雌性垂体FSH升高。在第0天和第1天注射丙酸睾丸激素（TP）可以防止新生的经睾丸切除的雄性脱敏，并使雌性在成年期对T抑制强直性FSH分泌的敏感性更高。在成年期第0天和第1天注射雌二醇苯甲酸酯（EB）不会影响补体FSH对T的反应，尽管这些雌性是无排卵的并且具有男性化的生殖器。;在成年仓鼠中，雌二醇-17β（E（，2））和5α-二氢睾丸激素（DHT）阻止了血清FSH对兰花切除术的反应。 E（，2）阻止了血清FSH对卵巢切除术的反应，但DHT在这方面无效。新生儿兰花切除术使成年人对DHT抑制FSH分泌无反应。新生儿TP处理导致7名女性中有2名在成年期对DHT抑制滋补FSH分泌产生反应。 ）产后早期的睾丸雄激素作用会增强雄激素（即DHT）抑制滋养FSH分泌的能力，并且（c）雄激素的这种早期组织作用不是由芳香化为E（，2）介导的。因此，在新生儿发育过程中，介导雄激素抑制补品FSH释放的机制会发生性别分化。

著录项

  • 作者

    HUTCHISON, JAMES SCOTT.;

  • 作者单位

    University of Connecticut.;

  • 授予单位 University of Connecticut.;
  • 学科 Animal Physiology.
  • 学位 Ph.D.
  • 年度 1982
  • 页码 144 p.
  • 总页数 144
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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