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The Effect of Three-Year Weight History on Quantitative Ultrasound Parameters in Older Mainland Chinese Women and Men.

机译：三年体重史对中国大陆老年人的定量超声参数的影响。

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摘要

Background: Finding risk factors for poor bone quality that are relevant to China is useful for targeting higher-risk women for bone quantitative ultrasound (QUS) testing. Weight history has typically been measured as the difference in weight between two time points. Incorporating an additional indicator of weight variability over this time period may enhance this measure.;Objective: To examine the relationship between bone QUS and weight history (including weight variability) in pre and postmenopausal women, women transitioning into menopause (TIM) and men over 65 years of age.;Methods: This was a retrospective, clinic-based study of 1201 postmenopausal, 862 pre-menopausal and 419 TIM women, and 424 older men in Guangdong Province, China. Weight was measured yearly over a three year period. Weight history over 3 years was defined as (1) weight trend (the slope of weight on year) and weight variability (the root mean square error (RMSE) around the slope of weight on year) (2) weight trajectories (3-year trajectories estimated by growth mixture modeling), and (3) weight change (the percent change in weight from baseline). Stiffness index (SI) of the os calcaneus [assessed using a Lunar Achilles Insight QUS device (GE Medical Systems Inc., USA)], age, height and weight were measured once at the end of year 3. Z-scores were used to compare regression lines for predicting SI from the weight history variables among study groups.;Results: Weight variability (weight-RMSE) was significantly and negatively associated with SI, independent of weight, weight trend, age and height (beta = -1.32; P< 0.03) among postmenopausal women. No other associations between weight history and SI were detected. Slopes for the association between SI and weight-RMSE were not significantly different between postmenopausal women and the other study groups.;Conclusions: This study provides evidence that measuring weight variability, in addition to weight change, may provide a more complete assessment of the influence of weight history on bone. Further work is needed to investigate methods of quantifying weight variability that could be used in a clinical setting.
机译：背景：寻找与中国相关的骨质不良的危险因素，有助于将较高风险的女性作为骨定量超声（QUS）测试的对象。体重史通常被测量为两个时间点之间的体重差异。目的：研究绝经前和绝经后女性，更年期女性（TIM）和男性绝经后女性的骨质疏松症（QUS）与体重史（包括体重变异性）之间的关系。 65岁；方法：这是一项回顾性临床研究，来自中国广东省的1201绝经后女性，862绝经前女性和419 TIM女性，以及424老年男性。在三年中每年测量一次体重。超过3年的体重史定义为（1）体重趋势（体重的斜率）和体重变异性（体重斜率的均方根误差（RMSE））（2）体重轨迹（3年） （3）重量变化（相对于基线的重量变化百分比）。跟骨的刚度指数（SI）[使用Lunar Achilles Insight QUS设备（美国GE Medical Systems Inc.评估）]，在第3年末测量一次年龄，身高和体重。使用Z分数结果组：体重变异性（weight-RMSE）与SI呈显着负相关，与体重，体重趋势，年龄和身高无关（β= -1.32； P <0.03）。体重史和SI之间未发现其他关联。绝经后妇女与其他研究组之间，SI和体重-RMSE之间的关系的斜率没有显着差异。骨骼上的体重史。需要进一步的工作来研究可用于临床环境的量化体重变异性的方法。

著录项

  • 作者

    Sanchez, Ana Maria.;

  • 作者单位

    University of Maryland, Baltimore.;

  • 授予单位 University of Maryland, Baltimore.;
  • 学科 Epidemiology.;Public health.;Gerontology.;Asian studies.
  • 学位 Ph.D.
  • 年度 2015
  • 页码 170 p.
  • 总页数 170
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 地球物理学;
  • 关键词

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