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首页> 外文学位 >Atherosclerosis Plaque Neovascular Inflation Using Ultrasound Strain Imaging.
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Atherosclerosis Plaque Neovascular Inflation Using Ultrasound Strain Imaging.

机译：使用超声应变成像的动脉粥样硬化斑块新生血管充盈。

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摘要

Vasa vasorum (VV) are small arterial and venous networks that originate from major arteries and drain into major veins; penetrating into the arterial wall to supply oxygen and nutrition for the tissues on the outer layer of the vessel walls and draining the by-products of metabolism. In the case of atherosclerosis, VV may grow into the plaque and supply the cells inside, which contribute to the progression of atherosclerosis and increase the risk of future plaque rupture. Additionally, VV could also be a source of intraplaque pressure that inflates the plaque when the luminal pressure decreases below a certain threshold during the cardiac cycle. Such cyclic inflations could pose another risk factor of a vulnerable plaque as the dynamics during inflations could weaken the caps of plaque. A sudden change between the intraplaque pressure and the luminal pressure would incur more inflation stress on the plaque cap and thus increase the likelihood of plaque rupture. Therefore, the density of VV within an atherosclerotic plaque could be an important factor to estimate the vulnerability.;Ultrasound strain imaging is a technique that can be used to measure non-invasively how much a plaque inflates during a cardiac cycle, which could be associated with the volume of VV inside the plaque. In addition, the peak-systolic velocity (PSV) within the stenosis affects the plaque inflation due to the Bernoulli Effect.;The work in the thesis focuses on a pilot study to research how the carotid plaque inflates among carotid atherosclerosis patients with ultrasound strain imaging, and relates the inflation with the PSVs measured by spectral Doppler. 22 carotid stenosis cases were studied and the results show that most carotid plaques inflate during cardiac cycle, and inflations correlate with PSV. The results provide encouraging evidence to the VV inflation hypothesis and pave the path to future in-depth research on larger population of patients.
机译：脉管脉管（Vasa vasorum，VV）是小型动脉和静脉网络，起源于主要动脉并排入主要静脉。渗透到动脉壁以为血管壁外层的组织提供氧气和营养，并排出新陈代谢的副产物。在动脉粥样硬化的情况下，VV可能长入斑块并供应内部的细胞，这有助于动脉粥样硬化的发展并增加将来斑块破裂的风险。另外，VV也可能是斑块内压力的来源，当腔内压力在心动周期内降低至某个阈值以下时，斑块内压力会使斑块膨胀。这种周期性的通货膨胀可能构成易损斑块的另一个风险因素，因为通货膨胀期间的动态可能会削弱斑块的上限。斑块内压力与腔内压力之间的突然变化将在斑块帽上引起更大的膨胀应力，因此增加了斑块破裂的可能性。因此，动脉粥样硬化斑块中VV的密度可能是评估脆弱性的重要因素。超声应变成像是一种可用于无创测量心动周期中斑块膨胀多少的技术，这可能与斑块内的VV量。此外，由于伯努利效应，狭窄内的收缩期峰值速度（PSV）影响斑块膨胀。本论文的重点是通过超声应变成像研究在颈动脉粥样硬化患者中颈动脉斑块膨胀的初步研究。 ，并将通货膨胀与通过频谱多普勒测得的PSV相关联。研究了22例颈动脉狭窄病例，结果表明，大多数颈动脉斑块在心动周期中会膨胀，并且膨胀与PSV相关。结果为VV充气假说提供了令人鼓舞的证据，并为将来对更大范围的患者群体进行深入研究铺平了道路。

著录项

  • 作者

    Xu, Canxing.;

  • 作者单位

    University of Washington.;

  • 授予单位 University of Washington.;
  • 学科 Biomedical engineering.;Medical imaging.;Pathology.
  • 学位 Masters
  • 年度 2014
  • 页码 39 p.
  • 总页数 39
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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