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Carbon-based nanoprobes for cell nanosurgey & biological applications.

机译：碳基纳米探针，用于细胞纳米外科和生物应用。

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Medical and biological science aims to study the intimate processes of living cells with minimal impact or inhibition of their normal activity. To this end, one can envision how tools with nanoscopic features would be able to minimally interact with cellular processes at a sub-cellular or even molecular level. Nanoscale carbon-based structures, such as carbon nanotubes and nanopipes, are one such nanoscopic structure gaining increased attention for nanosurgery and nanomedicine applications because of their unique and superior properties.;The abilities and shortcomings of previous carbon-based nanoprobes motivated the development of an alternative nanosurgery tool, the carbon nanopipette. Carbon nanopipettes integrate carbon nanopipes into the tips of pulled glass capillaries without assembly, thereby making the process amendable to mass production. An electrically-conductive carbon film coats the entire length of the glass micropipette's inner lumen, facilitating electrical interfacing and fluid transport through the nanoscopic carbon tip. Since carbon nanopipettes incorporate glass micropipettes, standard cell physiology equipment can be used to maneuver the probe to deliver materials to cells and sense cellular processes.;Carbon nanopipettes are manufactured without assembly and in quantity. Their composite carbon structure enables them to bend without breaking. Yet, carbon nanopipettes are rigid enough to penetrate into the interior of cells without causing them harm. Carbon nanopipettes are capable of concurrent fluid injection and electrical recording. Highlighting these capabilities, carbon nanopipettes injected calcium-mobilizing second messengers to identify signaling pathways in breast cancer cells and electrically recorded the intracellular response of hippocampal neurons to stimuli. Carbon nanopipettes offer a novel yet viable means of widely employing carbon-based nanoprobes in cell nanosurgery, medicine, and beyond.
机译：医学和生物学科学旨在研究活细胞的内在过程，而对它们的正常活动的影响或抑制却最小。为此，可以预见具有纳米特征的工具将如何能够在亚细胞甚至分子水平上与细胞过程最小程度地相互作用。纳米级碳基结构，例如碳纳米管和纳米管，由于其独特和优越的性能而成为越来越受到纳米外科和纳米医学应用关注的一种纳米结构;以前的碳基纳米探针的能力和不足促使了纳米碳管的发展。纳米外科手术的替代工具，碳纳米管。碳纳米管无需组装即可将碳纳米管整合到拉制的玻璃毛细管的尖端中，从而使该工艺可进行批量生产。导电碳膜覆盖了玻璃微量移液器内腔的整个长度，从而有助于电接口和流体通过纳米级碳尖端的传输。由于碳纳米移液管结合了玻璃微量移液管，因此可以使用标准的细胞生理设备操纵探针以将材料输送到细胞并检测细胞过程。碳纳米移液管无需组装即可大量生产。它们的复合碳结构使它们能够弯曲而不会断裂。然而，碳纳米移液管具有足够的刚性，可以穿透细胞内部而不会造成伤害。碳纳米移液器能够同时进行流体注入和电记录。突出这些功能的是，碳纳米移液器注入了可动员钙的第二信使，以识别乳腺癌细胞中的信号传导途径，并电记录海马神经元对刺激的细胞内反应。碳纳米移液器提供了一种新颖而可行的方法，可以在细胞纳米外科，医学及其他领域广泛使用基于碳的纳米探针。

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