目的:探讨芜湖市中老年人群胰岛素抵抗情况及其影响因素.方法:横断面调查芜湖市中老年人群1 046名,问卷调查并检测血清胰岛素水平,采用稳态模型法估测人体胰岛素抵抗程度.结果:胰岛素抵抗指数平均水平为0.24±0.34,男性为0.20±0.30,女性为0.26±0.36,差异有统计学意义(t=2.74,P=0.01).校正年龄、职业、文化程度后,Logistic逐步回归分析显示,男性胰岛素抵抗的危险因素有高血糖(OR=5.032,P=0.000)、高甘油三酯血症(OR=1.972,P=0.014)、肥胖(OR=1.744,P=0.046),而摄入油脂类型(OR=0.539,P=0.005)是其保护因素;女性胰岛素抵抗的危险因素有高血糖(OR=2.980,P=0.000)、高低密度脂蛋白血症(OR=2.539,P=0.002)及体育锻炼(OR=1.263,P=0.006).结论:高血糖、高血脂及肥胖可能是该地区中老年人群胰岛素抵抗的危险因素.%Objective: To investigate the status of insulin resistance(IR ) and its influencing factors among the middle-aged population living in Wuhu city,Anhui province, China. Methods: A cross-sectional study was performed in 1 046 middle-aged subjects with self-programmed questionnaire. The serum insulin was detected, and degree of 1R was estimated u-sing the homeostasis model assessment(HOMA ) method. Results: The average HOMA-IR was 0. 24 ± 0. 34 , and the difference was significant between male( 0. 20 ± 0. 30 ) and female( 0. 26 ± 0. 36 )( t = 2. 74, P = 0.01 ). After adjustment for the ages, occupation and education levels, stepwise multivariate logistic regression analysis suggested that hypergly-cemia( OR = 5. 032 ,P = 0. 000 ), high TG( OR = 1. 972,P = 0. 014 ) and obesity ( OR = 1. 744 , P = 0. 046 ) were the risk factors for males, yet the daily intake of fatty type ( OR = 0. 539, P = 0. 005 ) was associated with beneficial factors to IR. Risk factors for females were involved in hypergly-cemia( OR =2. 980 ,P =0. 000 ) ,high LDL-C( OR = 2. 539 ,P = 0. 002 ) and insufficient exercise ( OR =1. 263 , P = 0. 006 ). Conclusion: llyper-glycemia, hyperlipidemia and obesity appear to be risk factors for IR in the middle-aged population living in Wuhu areas.
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