目的:观察注射用盐酸伊立替康溶血和凝集、局部血管刺激性及致过敏作用.方法:采用家兔红细胞悬液致溶血和凝集试验、家兔耳缘静脉局部血管刺激性试验及豚鼠全身主动过敏试验.结果:注射用盐酸伊立替康未见致溶血及致凝集作用;对家兔耳缘静脉注射无明显刺激反应;豚鼠致敏试验静脉用药2 h内未见全身主动过敏反应.结论:动物实验表明,盐酸伊立替康用于注射给药是安全可靠的.%Objective :To observe the hemolysis and agglutination, local vascular irritation and allergenic effect of irinotecan hydroehloride injection. Methods:Determination of hemolysis and agglutination was conducted with red cell suspension, the local vascular irritation was performed in rabbits through intravenous drip of irinotecan hydrochloride and systemic active anaphylaxis was carried out in guinea-pigs. Results: Intervention with irinotecan hydrochloride caused hardly hemolysis and agglutination,and induced no stimulus response in the ear vein of the rabbits and systemic active anaphylaxis in the guinea-pigs in 2 hours as well.Conclusion :The experiments on animals show that irinotecan hydrochloride is safe for intravascular injection.
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