The stratum corneum layer of the skin plays critical roles in maintaining the integrity of skin structure and barrier function. Its non-invasive monitoring is therefore very important. In this in vivo study, the mouse ear was used as a model. The acetone-mediated exfoliating process was monitored by time-domain optical coherence tomography ( TD-OCT) . Results demonstrated that OCT imaging could be used to obtain the thickness of the stratum corneum layer and to monitor the exfoliating process. OCT imaging has clinical potentials in studying the structure and function of skin barrier.%皮肤角质(stratum corneum,SC)在维持皮肤结构完整和屏障功能中发挥重要作用,其无损检测很有意义.本文使用鼠耳模型,利用时域光学相干断层成像(TD-OCT)技术对丙酮去角质化的过程进行了检测.结果显示TD-OCT成像方法可测量角质层厚度、对去角质化做定性分析,在皮肤结构和屏障功能的无损检测中有一定临床价值.
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