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首页> 外文期刊>中国药理学报：英文版 >葛根素抑制大鼠背根神经节细胞河豚毒素不敏感性钠电流
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葛根素抑制大鼠背根神经节细胞河豚毒素不敏感性钠电流

机译：葛根素抑制大鼠背根神经节细胞河豚毒素不敏感性钠电流

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To test if puerarin (Pue) affects slow sodium current in dorsal root ganglion (DRG) neurons.METHODS: Tetrodotoxin resistant (TTXr) sodium current was recorded with whole cell patch clamp technique on DRG neurons of young adult rats.TTXr sodium current by 9.5 % - 83.2 %. The inhibition was concentration-dependent and partially reversible, but was not use-dependent nor voltagedependent. Pue did not affect the inactivation but changed the potential for half maximal conductance from - 26 mV to - 16 mV, suggesting the activation process was inhibited. CONCLUSION: Pue moderately inhibits TTXr sodium current of rat DRG neurons.%测定葛根素(Pue)对大鼠背根神经节(DRG)细胞河豚毒素不敏感性(TTXr)钠电流的作用.方法:采用全细胞钳制技术,记录成年Wistar大鼠DRG神经元中TTXr钠电流.结果:Pue在0.01-2 mmol·L-1浓度范围内,对TTXr钠电流的抑制率为9.5%-83.2%.该抑制作用为浓度依赖性,可部分洗脱,但非频率依赖性或电压依赖性.Pue不影响失活曲线,但使1/2最大激活电压由-26 mV升至-16 mV,说明抑制了激活过程.结论:Pue抑制大鼠DRG细胞中TTXr钠电流.
机译：To test if puerarin (Pue) affects slow sodium current in dorsal root ganglion (DRG) neurons.METHODS: Tetrodotoxin resistant (TTXr) sodium current was recorded with whole cell patch clamp technique on DRG neurons of young adult rats.TTXr sodium current by 9.5 % - 83.2 %. The inhibition was concentration-dependent and partially reversible, but was not use-dependent nor voltagedependent. Pue did not affect the inactivation but changed the potential for half maximal conductance from - 26 mV to - 16 mV, suggesting the activation process was inhibited. CONCLUSION: Pue moderately inhibits TTXr sodium current of rat DRG neurons.%测定葛根素(Pue)对大鼠背根神经节(DRG)细胞河豚毒素不敏感性(TTXr)钠电流的作用.方法:采用全细胞钳制技术,记录成年Wistar大鼠DRG神经元中TTXr钠电流.结果:Pue在0.01-2 mmol·L-1浓度范围内,对TTXr钠电流的抑制率为9.5%-83.2%.该抑制作用为浓度依赖性,可部分洗脱,但非频率依赖性或电压依赖性.Pue不影响失活曲线,但使1/2最大激活电压由-26 mV升至-16 mV,说明抑制了激活过程.结论:Pue抑制大鼠DRG细胞中TTXr钠电流.

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