LANC was randomly divided into IAC,intra-arterial neoadjuvant chemotherapy followed by concurrent chemo-radiotherapy and IVC,intravenous neoadjuvant chemotherapy combined with radiotherapy.After 4 weeks, the complete remission rate (CR)in group IAC and IVC was 94.0% vs 70.0%,with statistical significance (P 0.05).Intra-arterial induction chemotherapy followed by concurrent chemo-radiotherapy has obvious effect on LANC and perform safely.%将局部晚期鼻咽癌患者分为动脉灌注化疗联合放疗（IAC）组和静脉诱导化疗联合放疗（IVC）组。治疗后4周， IAC 组与 IVC 组的完全缓解（CR）率分别为94．0％、70．0％，差异有统计学意义（P ＜0．05）；治疗后12周，IAC 组与 IVC组的 CR 率分别为98．0％、72．0％，差异有统计学意义（P ＜0．05）。两组治疗有效率均为100％，均未发现远处转移病例。两组之间3、4级急性毒副反应发生率比较，差异无统计学意义（P ＞0．05）。因此动脉灌注诱导化疗联合后期同步放化疗疗效可靠、安全。
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