Thl7 characterized by the production of interleukin (IL)-17 is a newly founded subset of CD4 T effect cells. Thl7 cyto-kines include IL-17, IL-17F, IL-21, tumor nuclear factor-a and so on. Th 17 have been linked to many chronic inflammatory diseases, autoimmune diseases and tumor. Several data indicated that Th17 response may play an important role in the development and progression of atherosclerosis. In this review,we will introduce the role of Thl7 in atherosclerosis.%效应性T细胞亚群Th17是新近发现的效应性T细胞的又一亚群,因分泌细胞因子IL-17而得名.Th17通过分泌多种效应分子如白细胞介素17、17F、21和肿瘤坏死因子-α等与慢性炎症性疾病、自身免疫性疾病和肿瘤等疾病密切相关.研究发现,动脉粥样硬化的发生发展也与Th17功能的异常密切相关,现拟就此进行综述.
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