Objective To explore the correlation between mycoplasma pneumonia infection and asthma in children,and provide reference for the prevention,diagnosis and treatment of asthma.Methods From June 2012 to June 2015,118 cases of children with asthma were chosen,passive agglutination method with Mycoplasma pneumoniae enzyme-linked immunosorbent assay were used to test positive rate of antibody (MP-IgM) and analyzed clinical features of mycoplasma infection in asthmatic children.Results For 118 cases of children with asthma,the case number induced by respiratory tract infection factors by allergic,sports and other factors were 89 cases (75.4%),14 cases (11.9%),9 cases (7.6%),6 cases (5.1%),respectively;infection by bacteria,virus and,MP infection were 26 cases (29.3%),19 cases (21.3%),44 cases (49.4%);118 serum samples of children with asthma,44 serum samples were MP-IgM positive,the positive rate was 37.3%;for comparison of asthma children's gender,the positive rate of female children of MP-IgM was higher than that of male patients,the difference was statistically significant (χ2=4.182,P=0.041);for comparison the positive rate of MP-IgM between different age groups,the positive rate of asthma in preschool children with MP infection were 48.4%,which was the highest,and there were statistically significant differences between the three groups (χ2=6.882,P=0.032);MP positive rate of atopic asthma physical children was higher than the children without constitution atopic children,with a statistically significant difference (χ2=5.497,P=0.019).Conclusion Mycoplasma pneumoniae infection is an important predisposing factor of asthma in children,Mycoplasma pneumoniae infection was influenced by the children gender,age and host atopic constitution.%目的 探讨肺炎支原体(MP)感染与儿童哮喘的关系,为儿童哮喘的临床诊治提供参考依据.方法 选取2012年6月-2015年6月收治的118例哮喘发作患儿,采用酶联免疫吸附法检测入组儿童血清中肺炎支原体抗体(MP-IgM),比较其感染MP-IgM的阳性率,并分析哮喘患儿支原体感染的临床特点.结果 118例哮喘发作患儿中,由呼吸道感染因素、过敏因素、运动因素、其他因素诱发的分别为89例(75.4%)、14例(11.9%)、9例(7.6%)、6例(5.1%);呼吸道感染因素诱发中由细菌感染、病毒感染、MP感染诱发的分别为26例(29.3%)、19例(21.3%)、44例(49.4%);118份哮喘患儿血清学标本中,MP-IgM 阳性血清标本44份,阳性率为37.3%;哮喘儿童性别比较,女性患儿MP-IgM阳性率高于男性患儿,差异有统计学意义(χ2=4.182,P=0.041);不同年龄段MP-IgM阳性率比较,学龄前期哮喘患儿MP感染阳性率最高,为48.4%,高于婴幼儿组和学龄期组,三组间差异有统计学意义(χ2=6.882,P=0.032);具有特应性体质的哮喘患儿MP-IgM阳性率明显高于不具有特应性体质患儿,差异有统计学意义(χ2=5.497,P=0.019).结论 MP感染是儿童哮喘发作的重要诱发因素,MP感染诱发哮喘与性别、年龄及宿主的特应质体质有关.
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