首页> 中文期刊> 《肿瘤药学》 >阴道菌群与人乳头瘤病毒感染及宫颈病变的相关性研究进展

阴道菌群与人乳头瘤病毒感染及宫颈病变的相关性研究进展

         

摘要

Vaginal microbiota plays a crucial role in vaginal health. In recent years, our understanding of vaginal bacterial community composition and structure has been significantly broadened as a result of investigators using cultivation-independent methods based on the analysis of 16S ribosomal RNA (rRNA) gene sequences. The healthy human vagina is dominated by lactobacilli, which play an important role in protecting the host from urogenital infections. By the analysis of the vaginal microbiome associated with human papillomavirus infec-tion, cervical precancer and cervical cancer, researchers find that occurrences of lesions are associated with the number and the increasing diversity of specific genus bacteria. We will explain the relationship between vaginal flora and HPV infection and cervical lesions in terms of the composition of the vaginal flora and its regulatory mechanisms.%阴道菌群对维系女性生殖道的健康有着重要的作用.随着16SrRNA基因测序方法的发展,人们对阴道菌群的组成及结构有了更深入的认识.乳杆菌主导着健康女性的阴道环境,在保护女性泌尿生殖系统免受病原菌感染方面起着重要作用.研究者在分析了人乳头瘤病毒(HPV)感染、宫颈癌前病变、宫颈癌及细菌性阴道炎等患者的阴道菌群后,发现病变的发生与特定菌属的数量及多样性增加相关.本文对阴道菌群与HPV持续感染、宫颈病变关系的研究进展作一综述,以进一步理解病原菌与乳杆菌如何相互作用并改变阴道内环境.

著录项

  • 来源
    《肿瘤药学》 |2019年第1期|10-13|共4页
  • 作者单位

    Central South University;

    Changsha;

    Hunan;

    410083;

    China;

    Hunan Cancer Hospital / The Affiliated Cancer Hospital of Xiangya School of Medicine;

    Central South University;

    Changsha;

    Hunan;

    410013;

    China;

    Hunan Cancer Hospital / The Affiliated Cancer Hospital of Xiangya School of Medicine;

    Central South University;

    Changsha;

    Hunan;

    410013;

    China;

    Hunan Cancer Hospital / The Affiliated Cancer Hospital of Xiangya School of Medicine;

    Central South University;

    Changsha;

    Hunan;

    410013;

    China;

    Hunan Cancer Hospital / The Affiliated Cancer Hospital of Xiangya School of Medicine;

    Central South University;

    Changsha;

    Hunan;

    410013;

    China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 子宫肿瘤;
  • 关键词

    阴道菌群; 人乳头状瘤病毒; 宫颈癌前病变; 宫颈肿瘤;

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