The new synthesis of isocytosine from ethyl acetate,ethyl formate,sodium methoxide and guanidine hydrochloride in one pot and two steps, avoiding of using fuming sulfuric acid was presented. Advantages of this new synthetic protocol included reducing environmental pollution,low price of raw materials and easy operation. The yield was up to 72%. It provided a novel synthetic route with potential industrial values.%本文以乙酸乙酯、甲酸乙酯、甲醇钠和盐酸胍为原料,通过一锅、两步反应合成重要的药物中间体异胞嘧啶.该方法能够避免使用发烟硫酸,减小了环境污染,所用原料价格低廉,条件易控制,后处理方便,收率达到72％.本研究为异胞嘧啶及类似物质的合成提供了一条新的途径,具有潜在的应用前景.
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