Four derivatives of trielosan were synthesized and their structures were confirmed by IR, 1HNMR, HRMS.The antibacterial activity of the new compounds against Staphylococcus aureus and Escherichia coli were tested, and one new compound could inhibit Escherichia coli and Staphylococcus aureus in concentration of 20μg/mL.%本论文对三氯新的结构进行了改造,合成了四个未见文献报道的三氯羟基二苯醚衍生物,它们的结构均经红外、核磁、高分辨质谱证实.对新化合物进行了抗金黄色葡萄球菌和大肠杆菌活性的测试,其中有一个新化合物在20ug/mL浓度下对两种菌都有活性.
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