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首页> 中文期刊> 《中国畜牧兽医》 >合生素和抗菌肽对肉仔鸡大肠杆菌病的防制效果及免疫调节作用

合生素和抗菌肽对肉仔鸡大肠杆菌病的防制效果及免疫调节作用

         
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摘要

试验旨在研究添加自制合生素和新型抗菌肽对肉仔鸡生长性能的影响,以及攻毒后对其免疫功能的调节作用.选取健康的1日龄科宝Ross 308肉仔鸡100只,随机分为4组.自制合生素组(S组)饲喂基础日粮+0.3%合生素;抗菌肽组(AP组)饲喂基础日粮+0.5%抗菌肽;抗菌肽+合生素组(SAP组)饲喂基础日粮+0.3%合生素+0.5%抗菌肽;对照组(C组)饲喂基础日粮.试验期间测定各组肉鸡生长性能;在试验第14天,同时每组随机选取10只肉仔鸡进行大肠杆菌O78攻毒(对照组攻毒后设为攻菌模型组(M组)),观察记录24 h各组鸡的发病和死亡情况,并测定肉仔鸡的免疫功能.结果显示,与对照组相比,S组和AP组料重比和平均日采食量显著降低(P<0.05),SAP组的法氏囊指数在攻毒前显著升高(P<0.05),其他各组无显著差异(P>0.05);攻毒后,S组及AP组的胸腺指数、脾脏指数及法氏囊指数均显著高于对照组(P<0.05),SAP组的脾脏指数、法氏囊指数均显著高于对照组(P<0.05),胸腺指数与对照组间无显著差异(P>0.05).攻毒后S组中IgA、sIgA和IL-10与M组无显著差异(P>0.05),而IL-6极显著降低(P<0.01);AP组中IgA和IL-6均极显著降低(P<0.01),sIgA和IL-10显著或极显著升高(P<0.05;P<0.01);SAP组的变化趋势与AP组相同.综上所述,日粮中分别添加合生素和抗菌肽可以提高肉仔鸡的饲料转化率;攻菌后,合生素和抗菌肽以及两者联合使用均可以提高肉仔鸡免疫功能.%This experiment was to study the effect of synbiotic and antibacterial peptide on growth performance,and the immune regulation of broiler chickens after the E.coli O78 attack.Totally 100 broilers of health 1-day-old Ross 308 were randomly divided into four treatment groups:Synbiotic group (group S) was fed with basal diet+0.3% synbiotic;Antibacterial peptides group (group AP) was fed with basal diet+0.5% antibacterial peptide;Antibacterial peptide+synbiotic group (group SAP) was fed with basal diet+0.3% synbiotic+0.5% antibacterial peptide;Control group (group C) was fed with basal diet,and the growth performance were determined.At the 14th day,10 chickens from each group were randomly selected for muscle injection with E.coli O78 (the attacked control group was named as model group (group M)),and after 24 h,the morbidity,mortality and immune function of chickens in each group were determined.The results showed that compared with control group,the F/G and ADF of groups S and AP were significantly decreased (P<0.05).Before E.coli O78 attack,the bursa index of group SAP was significantly higher than control group (P<0.05),and other groups had no significant difference (P>0.05);While after the E.coli O78 attack,the thymus,spleen and bursa indexes of groups S and AP were significantly higher than control group (P<0.05),the spleen and bursa indexes of group SAP were significantly higher than control group (P<0.05),and the thymus index showed no significant difference (P>0.05).Compared with the group M,the IgA,sIgA and IL-10 of group S showed no significant difference (P>0.05),while the IL-6 levels decreased extremely significantly (P<0.01);The IgA and IL-6 of group AP were extremely significantly decreased (P<0.01),meanwhile the sIgA and IL-10 were significantly or extremely significantly higher (P<0.05;P<0.01);The changed trend of SAP group was the same as the group AP.In conclusion,the synbiotic and antibacterial peptide could improve the feed conversion rate of chickens and they were used alone or combination all could improved chicken immune function after the bacteria attack.

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  • 来源
    《中国畜牧兽医》 |2017年第3期|888-895|共8页
  • 作者

    朱琪; 郭明; 何岚; 杨春蕾; 李玉鹏; 李海花; 乔家运; 王建国; 王文杰;

  • 作者单位

    天津市畜牧兽医研究所,天津 300381;

    天津市畜禽健康养殖技术工程中心,天津300381;

    河南农业大学牧医工程学院,郑州 450002;

    天津师范大学生命科学学院,天津300387;

    天津市畜牧兽医研究所,天津 300381;

    天津市畜禽健康养殖技术工程中心,天津300381;

    天津市畜牧兽医研究所,天津 300381;

    天津市畜禽健康养殖技术工程中心,天津300381;

    天津市畜牧兽医研究所,天津 300381;

    天津市畜禽健康养殖技术工程中心,天津300381;

    天津市畜牧兽医研究所,天津 300381;

    天津市畜禽健康养殖技术工程中心,天津300381;

    天津市畜牧兽医研究所,天津 300381;

    天津市畜禽健康养殖技术工程中心,天津300381;

    天津市畜牧兽医研究所,天津 300381;

    天津市畜禽健康养殖技术工程中心,天津300381;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 抗生素;
  • 关键词

    合生素; 抗菌肽; 肉仔鸡; 大肠杆菌病; 免疫;

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