目的：探讨临床治疗中晚期食管癌同步放化疗与序贯放化疗的疗效。方法将医院收治的156例中晚期食管癌患者随机分为同步放化疗组和序贯放化疗组，各78例，对比两组近期疗效、远期生存率及不良反应发生率。结果同步放化疗组和序贯放化疗组近期疗效相近，差异无统计学意义（P＞0.05）；同步放化疗组1年和2年生存率、不良反应发生率均高于序贯放化疗组，差异具有统计学意义（P＜0.05）。结论临床治疗中晚期食管癌时，同步放化疗与序贯放化疗近期疗效相同，但同步放化疗远期疗效良好，尽管不良反应比较多，但患者耐受性良好，不影响治疗。%Objective To study clinical treatment of advanced esophagus patients with CCRT and sequential chemoradiotherapy.Methods 156 cases of advanced esophageal cancer patients were divided into chemotherapy group and sequential chemotherapy group, 78 cases in each group, the incidence rate of long-term curative effect were compared between the two groups, the survival rate and adverse reaction. Results CCRT and sequential chemoradiotherapy recent treatment effect was similar, there were never statistically signiifcant difference (P>0.05), CCRT 1 year and 2 year survival rate were higher than sequential chemoradiotherapy, lower adverse reactions rate than sequential chemoradiotherapy, there were statistical significance (P<0.05).ConclusionClinical treatment of advanced esophageal carcinoma, radiotherapy and chemotherapy and sequential radiotherapy and chemotherapy in the near future curative effect is the same, but concurrent radiotherapy and chemotherapy curative effect is good, although many side effects, but patients tolerated well, does not affect the treatment.
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