Objective Analysis of application of serum cystatin C and serum creatinine in the diagnosis of chronic renal failure. Methods 62 cases of chronic renal failure patients admitted to our hospital as the research group, 52 cases of healthy physical examination were set as the control group. By enzyme method and immunoturbidimetry were measured in two groups of subjects of serum creatinine, serum cystatin C levels. The positive rate of statistics of two groups of serum creatinine and serum cystatin C levels and related indexes of patients in the study group. Results The control group, serum creatinine, serum cystatin C levels are lower than those of the study group, the difference between the two groups has statistical significance (P<0.05), serum creatinine in patients in the study group the positive rate and serum cystatin C positive rate, and the difference was statistically signiifcant (P<0.05). Conclusion Serum creatinine, serum cystatin C can be early renal failure as an important index of diagnosis, but serum cystatin C is serum creatinine value higher, clinical diagnosis of early chronic renal failure can be combined detection, and improve the detection rate.%目的：分析血清胱抑素C与血清肌酐在早期慢性肾功能衰竭诊断中的应用。方法我院收治的62例慢性肾功能衰竭患者作为研究组，将同期进行健康体检的52例设为对照组。由酶法、免疫比浊法分别测定两组研究对象的血清肌酐、血清胱抑素C水平。统计两组对象血清肌酐、血清胱抑素C水平及研究组患者相关指标阳性率。结果对照组血清肌酐、血清胱抑素C水平低于研究组，两组差异有统计学意义（P＜0.05）；研究组患者中血清肌酐阳性检出率与血清胱抑素C阳性检出率比较，差异有统计学意义（P＜0.05）。结论血清肌酐、血清胱抑素C均可作为早期肾功能衰竭的重要诊断指标，但血清胱抑素C较血清肌酐价值更高，临床诊断早期慢性肾功能衰竭可联合检测，进而提高其检出率。
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