首页> 中文期刊> 《中国麻风皮肤病杂志》 >糖皮质激素受体基因多态性与大疱性类天疱疮糖皮质激素抵抗的相关性研究

糖皮质激素受体基因多态性与大疱性类天疱疮糖皮质激素抵抗的相关性研究

         

摘要

Objective:To detect the genotype frequency of polymorphic loci( N363S, ER22/23EK, BclI, 9β) of glucocorticoid receptor ( GR ) gene to determine the correlation between glucocorticoid receptor gene polymorphism and glucocorticoid resistance in the patients with bullous pemphigus ( BP ) . Methods:Genomic DNA was extracted from the peripheral blood of the patients in the glucocorticoid sensitivity group ( 40 pa-tients) , glucocorticoid resistance group ( 48 patients) and 42 healthy controls. The mutations in polymorphic loci were detected by SNaPshotSNP. Results:Three kinds of genotypes (CC, CG and GG) of BclI were iden-tified in the three groups, with no significant difference among them ( P>0.05) . There was no polymorphism of N363S, ER22 / 23EK and 9β in the three groups. Conclusion: The polymorphism of GR gene may not be correlated with the glucocorticoid resistance in the patients with BP .%目的::检测糖皮质激素受体基因多态位点( N363S、ER22/23EK、BclI、9β),明确其与大疱性类天疱疮糖皮质激素(以下简称激素)抵抗的相关性。方法:提取激素敏感组(40例)、激素抵抗组(48例)及健康对照组(42名)外周血 DNA,应用 SNaPshotSNP 分型技术进行 GR 基因多态性位点( N363S、ER22/23EK、BclI、9β)检测。结果:激素敏感组、激素抵抗组和健康对照组均检出BclI有3种基因型CC、CG、GG,差异无统计学意义(P>0.05);N363S、ER22/23EK、9β基因位点不存在多态性。结论: GR基因N363S、ER22/23EK、BclI、9β多态性与BP激素抵抗可能无相关性。

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