Objective: To investigate the expression and significance of livin and cleaved caspase - 3 in condyloma acuminatum (CA). Method: The immunohistochemical SP method was applied to detect the expression of livin and cleaved caspase - 3 in 34 cases of CA and 15 normal skin controls. Results: The positive expression rates were 82.4％ for livin and 38.2％ for cleaved caspase - 3 in CA, both were significantly higher than that in normal skin ( P ＜ 0.01 ), where the expressions of the two proteins were both negative. The expression of livin and cleaved caspase - 3 was negatively correlated each other in CA ( r = - 5.25, P ＜ 0.01 ). Conclusion: livin may promote the development of CA by inhibiting the activation of caspase - 3. Both of livin and cleaved caspase - 3 may participate in the pathogenesis of CA.%目的:确定livin和 cleaved caspase-3在尖锐湿疣(condyloma acuminatum,CA)组织中的表达及意义.方法:采用免疫组化SP法检测livin和cleaved caspase-3在34例CA组织和15例正常皮肤组织中的表达.结果:正常皮肤中livin与cleaved caspase-3均无表达,CA组织中二者表达的阳性率分别为82.4%和38.2%;两种蛋白在CA组织中的表达呈负相关(r=-5.25,P＜0.001).结论:Livin抑制caspase-3的激活,两者共同参与CA的发病过程,可能与CA的发生、发展相关.
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