目的：分析妊娠合并临床甲状腺功能减退及亚临床甲状腺功能减退经激素替代治疗后妊娠结局。方法回顾分析2012年1月~2013年12月广东省深圳市南山区妇幼保健院产科92例临床甲状腺功能减退(OH组)及98例亚临床甲状腺功能减退妊娠妇女(SCHO组)，所有患者均给予左旋甲状腺素(L-T4)治疗，选择同期甲状腺功能正常的妊娠妇女300例作对照组，对三组进行妊娠结局分析比较。结果 OH组孕妇胎膜早破的发生率(27.2%)高于对照组(17.0%)，差异有统计学意义(P<0.05)；OH组和SCHO组孕妇早产、妊娠期高血压疾病、羊水过少、妊娠期糖尿病、产后出血、剖宫产率发生率与对照组比较，差异无统计学意义(P>0.05)。结论临床甲状腺功能减退和亚临床甲状腺功能减退孕妇经规范激素(L-T4)替代治疗不良妊娠结局发生情况与正常孕妇相似。%Objective To explore the pregnancy outcome on Hormone replacement therapy of clinical hypothyroidism and subclinical hypothyroidism during pregnancy. Methods 92 pregnancy women with clinical hypothyroidism (OH group)and 98 pregnancy women with subclinical hypothyroidism during pregnancy (SCHO group)from January 2012 to December 2013 in Department of Obstetrics of Nanshan District Maternal and Child Health Care of Shenzhen City were retrospectively analyzed, all these patients were given the treatment of sodiumlevothyroxine (L-T4), and 300 nor-mal pregnancy women in the same period were selected as control group. The outcome of pregnancy in three groups were analyzed. Results The incidence of premature rupture of membrane in OH group (27.2%) was higher than that in the control group (17.0%), the difference of two groups was statistically significant (P<0.05). There was no statistically significant difference in the occurrence rate of premature delivery, hypertensive disorder complicating pregnancy, oligo-hydramnios, gestational diabetes mellitus, postpartum hemorrhage, cesarean among the three groups (P>0.05). Conclu-sion The L-T4 replacement therapy of hypothyroidism during pregnancy can improve the adverse outcome of pregnancy.
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