Objective To understand the differences in efficacy and safety of Sodium Valproate in the treatment of migraine. Methods Homogeneity test and estimation of combined effect of Sodium Valproate and other treatments in tt treatment and prevention of migraine as demonstrated in the included literature were performed with Meta-analysis. An descriptive analysis of adverse reactions was also performed. Results In the topiramate subgroups, x2 = 0.13, df = 1 and = 0.72>0.05. The study is of homogeneity, using a fixed effects model analysis. And the statistical results were: OR = 0.9( 95% CI was [0.50, 1.84], Z = 0.12 and P = 0.91 >0.05, showing non-significant differences between the two groups; I non-care pyrazole ester sub-group, x2 = 2.15, df = 3, P = 0.54>0.05. The study is of homogeneity, using a fixed effec model analysis. And the statistical results were: OR = 4.83, 95% CI was [2.51, 9.28], P < 0.000 01, showing significant: better treatment results in the treatment group than in the control group. Conclusion Sodium Valproate shows significai differences in efficacy and adverse reactions in the treatment and prevention of migraine compared with the control grou] thus is an effective and safe treatment and prevention of migraine.%目的 了解丙戊酸钠治疗偏头痛有效性及安全性的差异.方法 应用Meta分析对纳入文献研究中丙戊酸钠与其他治疗偏头痛的药物在治疗预防偏头痛有效性上进行同质性检验及合并效应量的估计.并对不良反应进行描述性分析.结果 在托吡酯亚组中,χ2 = 0.13,df = 1,P = 0.72＞0.05,该研究具有同质性,应用固定效应模型分析,统计结果OR = 0.96,95%CI[0.50,1.84],Z = 0.12,P = 0.91＞0.05,二者无显著差异;在非托吡酯亚组中,χ2 = 2.15,df = 3,P = 0.54＞0.05,研究具有同质性,应用固定效应模型分析,统计结果OR = 4.83,95%CI[2.51,9.28],P ＜ 0.000 01,二者有显著差异,治疗组优于对照组.结论 丙戊酸钠在治疗预防偏头痛上与对照组比较在疗效及不良反应上有显著差异,在治疗预防偏头痛上是安全有效的.
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