Objective To observe the efficacy of different doses of Methylprednisolone therapy on abdominal henoch-schonlein purpura (HSP) in children, in order to explore the better therapeutic schedule. Methods 96 cases of children with abdominal HSP were selected and treated with Methylprednisolone in our hospital from November 2010 to November 2011. The patients were randomly divided into low-dose group [2 mg/(kg·d)], middle-dose group [5-10 mg/(kg·d)] and high-dose group [15-30 mg/(kg·d)]. The recovery time of abdominal pain (gastrointestinal bleeding) and adverse reactions were observed. Results Low-dose group had no significant adverse reaction, but the recovery time of abdominal pain (gastrointestinal bleeding) in the low-dose group was longer than that in the middle-dose group and high-dose group (P < 0.05). While the recovery time of abdominal pain (gastrointestinal bleeding) had no significant difference between the middle-dose group and high-dose group (P > 0.05). The adverse reaction of the middle-dose group was less than that of the high-dose group (P < 0.05). Conclusion Middle dosage and high dosage Methylprednisolone therapy on abdominal HSP can relieve abdominal pain and gastrointestinal bleeding symptom early, and the middle dosage group has lower incidence of adverse reaction, which is more economical.%目的 观察不同剂量甲基强的松龙治疗腹型过敏性紫癜的治疗效果,以探索更好的治疗方案.方法 选取2010年11月～2011年11月我院96例腹型过敏性紫癜患儿给予甲基强的松龙治疗,随机分为小剂量组[2 mg/(kg·d)]、中剂量组[5～10 mg/(kg·d)]和大剂量组[15～30 mg/(kg·d)],观察腹痛(或消化道出血)缓解时间及不良反应.结果 小剂量组未见明显不良反应,但腹痛(或消化道出血)缓解时间明显较中、大剂量组长(P < 0.05),而中、大剂量组的腹痛(或消化道出血)缓解时间差异无统计学意义(P > 0.05);中剂量组的不良反应明显少于大剂量组(P < 0.05).结论 中剂量及大剂量应用甲基强的松龙,均可早期缓解过敏性紫癜患儿腹痛及消化道出血症状,减轻患儿痛苦,中剂量组不良反应发生率更低,且更为经济.
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