目的 探讨血清肝素结合蛋白(HBP)在脓毒血症患者急性肾衰竭过程中的表达与意义,了解其临床价值.方法 选取2014年9月～2017年9月于首都医科大学附属北京潞河医院急诊就诊的124例脓毒血症患者,根据是否发生急性肾衰竭分为脓毒血症急性肾衰竭组42例(A组),脓毒血症无急性肾衰竭组82例(B组),另选取非脓毒血症急性肾衰竭患者60例(C组),以及60名健康志愿者(D组)作为健康对照组.每组分别在入院24 h内及在相应治疗后采集静脉血,测定血清中HBP和血肌酐浓度水平.结果 治疗前,脓毒血症患者与健康对照组比较,A组和B组HBP水平明显高于C组和D组(P ＜ 0.05),而发生急性肾衰竭的A组血清中HBP浓度较B组明显升高(P ＜ 0.05).治疗后,只有A组HBP水平有明显下降(P ＜ 0.05).结论 HBP 可作为评估脓毒血症患者急性肾衰竭的发生指标,也可作为评价其治疗效果的一种方法.%Objective To investigate the purpose of this study was to investigate the expression and significance of serum heparin binding protein (HBP) in the process of acute renal failure in patients with sepsis and to understand its clinical value. Methods From September 2014 to September 2015, 124 patients with sepsis admitted to the emergency Department of Beijing Luhe Hospital Affiliated to Capital Medical University were selected. According to the occurrence of acute renal failure, 42 patients in the acute renal failure group with sepsis (group A), 82 patients in the group without acute renal failure group with sepsis (group B), 60 patients with acute renal failure without sepsis (group C), and 60 healthy volunteers (group D) were selected as the healthy control group. Venous blood was collected in each group within 24 h after admission and after corresponding treatment, and serum HBP and serum creatinine concentrations were measured. Results Before treatment, compared with the healthy control group, the HBP level of group A and group B was significantly higher than that of group C and group D (P ＜ 0.05), while the serum HBP level of group A with acute renal failure was significantly higher than that of group B (P ＜ 0.05). After treatment, only group A showed A significant decrease in HBP level (P ＜ 0.05). Conclusion HBP can be used as a method to evaluate the occurrence of acute renal failure in patients with sepsis and to evaluate its therapeutic effect.
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