目的 探讨降钙素原在基层医院急性发热患者中应用抗生素的指导价值.方法 随机将200例急性呼吸道感染性发热患者分为常规组与PCT组各100例.常规组在进行常规监测后根据抗生素应用标准使用抗生素治疗,PCT组在常规组的监测基础上进行PCT值检测,并在PCT值指导下决定用药方案及使用抗生素.观察两组的抗生素使用率及合理率、失误率、滥用率,以及抗生素使用时间及治疗费用等情况. 结果 两组患者临床治疗效果方面比较(P>0.05);观察组的治疗总时间为(6.13±1.17)d,对照组为(8.03±2.43)d,两组比较(P<0.05).PCT组在抗生素使用率、持续使用时间以及抗生素费用方面均明显少于常规组(P<0.05).细菌感染患者的PCT、CRP及WBC均较病毒感染、非感染患者高(P<0.05).结论 通过检测患者体内的PCT值,可以精准判断患者属于细菌发热或非细菌发热,指导使用抗生素,可使抗生素得到合理的使用,显著改善抗生素滥用的现状,节约医疗资源,降低医疗费用.%Objective To investigate the application of procalcitonin guidance value of antibiotics in acute febrile patients of primary hospital. Methods 200 cases with acute respiratory infection and fever were allocated into a conventional group and a PCT group,100 cases in each group.After carrying out routine monitoring of the conventional group of antibiotics used in accordance with standard antibiotics,the PCT group values detected in the monitoring group further received PCT value guidance.Antibiotic usage and reasonable rates,the error rate,the abuse rate,and the time and cost of treatment of antibiotic use and so on were observed.Results The clinical results between the two groups of patients (P>0.05);The total time of the treatment group was (6.13±1.17)d,the control group was (8.03±2.43) d,difference between the two groups (P<0.05).Antibiotic usage,time,and costs continued use of antibiotics in the PCT group were significantly less than those in the conventional group (P<0.05).PCT in patients with bacterial infections,CRP and WBC compared with a viral infection,high non-infected patients(P<0.05).Conclusion By detecting the patient PCT values,you can accurately determine a patient belongs to bacteria or bacterial fever,to guide the use of antibiotics,the rational use of antibiotics can significantly improve the status of the abuse of antibiotics,saving medical resources,reduce health care costs.
展开▼
