目的：探讨慢性阻塞性肺疾病(COPD)合并呼吸衰竭的有创-无创呼吸机序贯治疗疗效。方法选择本院2014年5~11月收治的COPD合并呼吸衰竭患者100例,随机分为序贯组(50例)和有创组(50例)。有创组患者进行有创机械通气至脱机,序贯组患者在有创机械通气后序贯进行无创机械通气。比较两组的疗效,观察两组患者的呼吸机相关性肺炎(VAP)发生率、总机械通气时间、有创通气时间、住院时间。结果序贯组有效率为96.00%,有创组有效率为82.00%,序贯组明显高于有创组(字2=5.005,P<0.05)；序贯组的VAP发生率为2.00%,低于有创组的16.0%(P<0.05)；总机械通气时间、有创通气时间、住院时间均少于有创组,差异有统计学意义(P<0.01)。结论有创-无创呼吸机序贯治疗COPD合并呼吸衰竭疗效显著,不良反应发生较少,缩短住院时间,值得临床进一步推广。%Objective To explore the efficacy of sequential therapy of invasive and noninvasive ventilation on chronic obstructive pulmonary disease (COPD) with respiratory failure. Methods 100 patients with COPD complicated with res-piratory failure in our hospital from May to November 2014 were randomly divided into sequence group (50 cases) and invasion group (50 cases).Invasion group were given invasive mechanical ventilation till evacuation,sequence group were received sequential therapy of invasive and noninvasive mechanical ventilation.Curative effect,incidence rates of venti-lator associated pneumonia (VAP),total time of ventilation, time of invasive ventilation,and time of hospitalization be-tween two groups was compared respectively. Results The curative effective rate was 96.00% in sequence group,signifi-cantly higher than 82.00%in invasion group (P<0.05).The incidence rate of VAP in Sequence group was 2%,less than 16% in invasion group (P<0.05).The total time of ventilation,time of invasive ventilation,and time of hospitalization in sequence group was shorter than that of invasion group respectively,with significant difference(P<0.01). Conclusion The curative effect of sequential therapy of invasive and noninvasive ventilation on COPD complictated with respiratory fail-ure is remarkable,and with less adverse reactions,can short the hospitalization time,is worthy of further promotion.
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