首页> 中文期刊> 《中国药业》 >硝苯地平长效与短效制剂治疗妊娠高血压临床随机对照研究

硝苯地平长效与短效制剂治疗妊娠高血压临床随机对照研究

         

摘要

Objective To study the clinical effect of long and short acting nifedipine on pregnancy induced hypertension . Methods Pregnancy induced hypertension patientsfrom June 2014 to June 2015 in the hospital were selected and divided into 2 groupsin accordance with the wishes of patients,40 cases of pregnancy induced hypertension patients were chosen and grouped. The two groups of patients were treated with magnesium sulfate,among them,the implementation of short acting nifedipine treatment group 15~25 mg,tid,(control group),another group was treated with nifedipine,30 mg,once 1 d(observation group) for 7 d. Theblood pres-sure,mode of delivery,neonatal conditions and complicationswere compared between the two groups of patients with pregnancy induced hypertension. Results The blood pressure,mode of delivery,neonatalconditionsin the observation group were better than the control group,and the incidence rate of complications was lower than that of the control group( P ﹤ 0. 05). Conclusion Longacting nifedipine treatment of hypertension in pregnancy is better than short acting nifedipine;thematernal blood pressure can be effectively controlled with good birth outcomes and fewer complications.%目的:对比研究硝苯地平长效与短效制剂对妊娠高血压的临床效果。方法选取2014年6月至2015年6月医院收治的妊娠高血压患者,按随机数字表法均分为2组,各40例。两组患者均使用硫酸镁治疗,对照组患者给予硝苯地平片15~25 mg∕次,每日3次;观察组患者给予硝苯地平缓释片30 mg,每日1次。两组疗程均为7 d。比较两组患者的血压、分娩方式、新生儿结局和并发症发生情况。结果治疗后,观察组患者的血压、分娩方式、新生儿结局均明显优于对照组患者,且并发症发生率低于对照组患者( P ﹤0.05)。结论硝苯地平长效制剂治疗妊娠高血压的临床效果好于硝苯地平短效制剂,产妇的血压能得到有效控制,且分娩结局好、并发症少。

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