Objective To discuss the influence of paclitaxel liposome combined with cisplatin in the three-dimensional conformal radio-therapy on the living quality of patients with advanced esophageal cancer. Methods 48 patients with advanced esophageal cancer from January 2011 to January 2012 were randomly divided into control group and observation group, 24 cases in each group. All patients were treated with three-dimensional conformal radiotherapy, and were combined with different chemotherapy regimens on the first day of radiotherapy, with docetaxel plus cisplatin chemotherapy ( observation group ) and five-fluorouracil plus cisplatin chemotherapy ( control group ) respectively. 4 weeks was 1 course of treatment, and with a total of 2 courses of treatment. Results After treatment, the recent curative effect of observation group was 91. 67%, which was significantly higher than 75. 00% in the control group ( P < 0. 05 ); the quality of life of the two groups of patients were significantly improved compared with before treatment, and the improvement in the ob-servation group was better than that of control group ( P < 0. 05 );symptoms such as dysphagia, pain and obstruction in the observation group were significantly better than the control group ( P < 0. 05 );at the end of follow-up, the 3 years survival rate of the observation group was higher than the control group ( P < 0. 05 );total incidence rate of adverse reactions in observation group was significantly low-er than the control group ( P < 0. 05 ) . Conclusion Paclitaxel liposome combined with cisplatin in the three-dimensional conformal ra-diotherapy in treating advanced esophageal cancer has a good short-term effect, can significantly improve the quality of life and clinical symptoms, improve the 3 years survival rate and has relatively fewer adverse reactions, which is worthy of clinical promotion.%目的 探讨紫杉醇脂质体、顺铂注射液联合三维适形放射治疗(简称放疗)对晚期食管癌患者生存质量的影响.方法 选择医院收治的晚期食管癌患者48例,随机分为对照组和观察组,各24例.所有患者均采用三维适形放疗,并于放疗第1天同步联合不同化学治疗(简称化疗)方案,观察组患者采用紫杉醇联合顺铂化疗方案,对照组患者采用5-氟尿嘧啶联合顺铂化疗方案,4周为1个疗程,共治疗2个疗程.结果 治疗后观察组近期疗效为91. 67%,显著高于对照组的75. 00%( P<0. 05);两组患者生存质量较治疗前均显著改善,且观察组改善程度更明显( P<0. 05);观察组患者吞咽困难、疼痛、梗阻、咳嗽等症状改善程度均显著优于对照组( P<0. 05);观察组患者3年生存率明显高于对照组( P<0. 05);观察组总不良反应发生率显著低于对照组( P<0. 05).结论 紫杉醇脂质体、顺铂注射液联合三维适形放疗治疗晚期食管癌,近期疗效好,能显著改善患者的生存质量及临床症状,提高3年生存率,且不良反应较少,值得推广.
展开▼
