目的:了解我院药品不良反应(ADR)的发生情况,以便更好地为临床用药提供切实的依据,保证用药的安全合理.方法:回顾性分析并统计我院2009年1月-2012年5月临床上报的1 419例报告.结果:1 419例ADR报告中,男性患者601例,女性患者818例；静脉滴注引发ADR 822例,占51.15％;发生ADR的人群主要以中老年患者为主.抗微生物药引起的ADR报告中,头孢菌素类抗微生物药引发例数最多,共计239例；皮肤及其附件损害所占比例最高(占38.63％).结论:临床用药中,应注意ADR对皮肤的影响,及对抗微生物药做过敏性试验,确保用药安全、有效.%OBJECTIVE: To investigate the occurrence of ADR in our hospital, and to provide reference for clinical drug use and guarantee the safety of drug use. METHODS: During Jan. 2009 —May 2012, 1 419 ADR cases reported in our hospital were analyzed retrospectively. RESULTS: Of 1 419 ADR reports, there were 601 male patients and 818 female patients. 822 cases were cause by intravenous dripping, accounting for 51.15%. ADR cases mostly occurred in middle-age and elderly group. Among ADR cases induced by antibiotics, a large number of cases were caused by cephalosporin antibiotics, involving 239 cases. Skin injury took up the highest proportion (38.63%). CONCLUSION: Great importance should be attached to the effect of ADR on gastrointestinal tract and sensitivity test of antibiotics to guarantee the safety and effectiveness.
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