OBJECTIVE: To evaluate the quo status and trend of oral antihypertensive drugs in the hospitals from Beijing area. METHODS: By retrospective method, the utilization of oral antihypertensive drugs in more than 40 hospitals from Beijing area during 2008 — 2011 was analyzed retrospectively in respect of drug types, consumption sum, DDDs and DDC, etc. RESULTS: The consumption sum of oral antihypertensive drugs in Beijing area increased year by year, increasing by 15.33% annually. Calcium-channel blockers(CCB),angiotensin Ⅱ receptor blocking agents(ARB) ,angiotensin-converting enzyme inhibitor(ACEI) and |3-re-ceptor blockers((5-RB) were the most frequently used antihypertensive drugs. The consumption sum of CCB accounted for over 41.23% of total consumption sum, and that of ARB, ACEI and fi-RB accounted for over 51.83%. Amlodipine, nifedipine, valsar-tan ranked at the first 3 place of consumption sum. In terms of DDDs, nifedipine ranked at the first place from 2008 to 2009, amlodipine took the lead in 2010, while phalosposporium sinensis took the lead in 2011. In terms of DDC, doxazosin was the highest from 2008 to 2011. CONCLUSION: The application of oral antihypertensive drugs is reasonable on the whole, and it conforms to the principle of antihypertensive drugs use. In the future, oral antihypertensive drugs with good efficacy, convenient route of administration and fewer side effects become the trend in clinical practice.%目的:评价北京地区医院口服抗高血压药的应用现状和趋势.方法:采用回顾性方法,对北京地区40余家医院2008-2011年口服抗高血压药的应用品种、销售金额、用药频度(DDDs)、日均费用(DDC)等进行统计、分析.结果:该地区医院所应用的口服抗高血压药年销售金额呈逐年上升趋势,年均增幅达15.33％.最常用的是钙通道阻滞药(CCB)、血管紧张素Ⅱ受体拮抗药(ARB)、血管紧张素转换酶抑制剂(ACEI)和β受体拮抗药(β-RB).其中,CCB的销售金额占口服抗高血压药总销售金额的41.23％以上,ARB、ACEI和β-RB的销售金额占口服抗高血压药总销售金额的51.83％以上.销售金额排序列前3位的药品均为氨氯地平、硝苯地平、缬沙坦.硝苯地平占据2008、2009年DDDs排名首位,氨氯地平占据2010年DDDs排名首位,虫草头孢菌丝占据2011年DDDs排名首位.多沙唑嗪的DDC在2008年到2011年均为最高.结论:该地区医院口服抗高血压药整体结构合理,符合当前抗高血压药应用的基本原则.疗效好、服用方便、不良反应小的药物是未来临床应用的方向.
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