OBJECTIVE:To observe the clinical efficacy and the cost-effectiveness ratio of hyaluronate sodium in the treatment of osteoarthrosis of knee.METHODS:80 patients of osteoarthrosis of knee were randomly divided into observation group and control group; observation group received hyaluronate sodium 25 mg,while control group was given Cervus and cucumis polypeptide 16 mg; clinical efficacies of 2 groups were observed and the cost-effectiveness ratios were compared.RESULTS:The total effective rate of observation group was 95.00％,while was higher than that of control group (70.00％) ; the cost-effectiveness (C/E) ratio of observation group was lower than that of control group,and the difference was statistically significant (P＜0.05).As for sensitivity analysis,the C/E of observation group was lower than that of control group,and the difference was statistically significant (P＜0.05).There was no ADR in both groups.CONCLUSIONS:Hyaluronate sodium is significantly effective in the treatment of osteoarthrosis of knee with low C/E ratio.%目的:评价玻璃酸钠治疗膝关节骨性关节炎的临床疗效及成本-效果.方法:将80例膝关节骨性关节炎患者随机均分为观察组和对照组,观察组患者给予玻璃酸钠注射液25 mg治疗,对照组给予鹿瓜多肽注射液16 mg治疗,观察两组患者的临床疗效,比较其成本-效果比.结果:观察组患者的总有效率为95.00％,显著高于对照组(70.00％),且成本-效果比(C/E)显著低于对照组,差异均有统计学意义(P＜0.05).经敏感度分析,观察组患者的C/E亦低于对照组,差异有统计学意义(P＜0.05).两组患者均未见不良反应发生.结论:玻璃酸钠治疗膝关节骨性关节炎的临床疗效显著,成本-效果更优.
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