Objective To analyze and explore the clinical effect of reteplase combined with reduced glutathione in treating acute ST segment elevation myocardial infarction (STEMI). Methods A total of 99 cases of acute ST segment elevation myocardial infarction were divided by random number table into observation group (49 cases) and control group (50 cases). The control group received reteplase treatment, and observation group received reteplase combined with reduced glutathione treatment. Comparison were made on vascular recanalization rate, clinical effect and incidence of adverse reactions in two groups. Results The observation group had vascular recanalization rate as 83.67%, total effctive rate as 91.84%, which were all higher than 66.00%, 76.00% in control group, and the differences had statistical significance (χ2=4.095, 4.581, P<0.05). The observation group had a lower incidenct of adverse reaction as 22.45% than 42.00% in control group, and the difference had statistical significance (χ2=4.324, P<0.05). Conclusion Reteplase combined with reduced glutathione show significant effect in treating acute ST segment elevation myocardial infarction, compared with reteplase only, and this method proves high safety.%目的：分析探讨瑞替普酶联合还原型谷胱甘肽治疗急性 ST 段抬高型心肌梗死(STEMI)的临床疗效。方法99例急性 ST 段抬高型心肌梗死患者,采用随机数字表法分为观察组(49例)和对照组(50例)。对照组患者采用瑞替普酶治疗,观察组患者采用瑞替普酶联合还原型谷胱甘肽治疗。比较两组患者的血管再通情况、临床疗效、不良反应发生情况。结果观察组血管再通率83.67%及总有效率91.84%均高于对照组66.00%、76.00%,差异均有统计学意义(χ2=4.095、4.581, P<0.05)。观察组不良反应发生率22.45%低于对照组42.00%,差异有统计学意义(χ2=4.324, P<0.05)。结论相对于单纯瑞替普酶治疗,联合还原型谷胱甘肽治疗急性 ST 段抬高型心肌梗死效果更为显著,且安全性高。
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