目的 探讨鼻咽癌组织中Maspin和Bmi-1的表达及其与临床病理特征的关系.方法 应用免疫组织化学法检测Maspin和Bmi-1在60例鼻咽癌及40例正常鼻咽组织中的表达情况,探讨两者表达的相关性及与鼻咽癌临床病理特征的关系.结果 Maspin在鼻咽癌及正常鼻咽组织中的阳性表达率分别为45.0%(27/60)和90.0%(36/40),差异有统计学意义(P<0.05).Bmi-1在鼻咽癌及正常鼻咽组织中的阳性表达率分别为75.0%(45/60)和25.0%(10/40),差异有统计学意义(P<0.05).Maspin和Bmi-1表达与年龄无关(P>0.05),而与肿瘤分化程度、淋巴结转移及临床分期有关(P<0.05).Maspin与Bmi-1在鼻咽癌组织中的表达呈负相关(r=-0.406,P<0.05).结论 Maspin和Bmi-1表达可能在鼻咽癌的发生、增殖和转移中起重要作用.%Objective To investigate the expression of Maspin and Bmi-1 in nasopharyngeal carcinoma and their relationship with clinical pathological characteristics. Methods An immunohistochemical method was used to detect the expression of Maspin and Bmi-1 proteins in 60 nasopharyngeal carcinoma samples and 40 adjacent normal nasopharyngeal tissues. Then the relationship between Maspin, Bmi-1 expression and clinicopathological features was analyzed. Results The positive expression rate of Maspin in nasophary-negeal carcinoma and normal tissues was 45. 0%(27/60) and 90. 0%(36/40) with significant difference(P<0. 05). The positive ex-pression rate of Bmi-1 in nasopharyngeal carcinoma and normal tissues was 75. 0%(45/60) and 25. 0%(10/40), and the difference was statistically significant( P<0. 05) . The expression of Maspin and Bmi-1 was not correlated with the age( P>0. 05) , but with the de-gree of malignancy, lymph node metastasis and clinical stage (P<0. 05).The expression of Maspin and Bmi-1 in nasopharyngeal carci-noma showed significant negative correlation( r=-0. 406,P<0. 05) . Conclusion The expression of Maspin and Bmi-1 plays an impor-tant role in the occurrence and progression of nasopharyngeal carcinoma.
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