目的：探讨尿肺炎链球菌抗原用于诊断儿童肺炎链球菌感染的临床意义。方法：收集2010年9月-2011年12月笔者所在医院住院部0~3岁呼吸道感染的患儿病例，对每位患儿同时采集尿标本和痰标本，用胶体金法测定尿肺炎链球菌抗原，对痰标本进行分离培养与鉴定，并根据结果分析。结果：尿肺炎链球菌抗原和痰培养检测差别无显著性(P>0.05)。痰培养阳性组和阴性组的尿抗原阳性率差异有显著性(P<0.01)。以痰培养为纯培养作为诊断肺炎链球菌感染的标准，胶体金法测抗原的灵敏度为86.00%，特异度为84.96%，准确度为85.25%。结论：胶体金法与痰培养在诊断肺炎链球菌感染方面可能具有同等的作用，胶体金法对临床诊断儿童肺炎链球菌感染具有一定的参考意义。% Objective:To know the urine streptococcus pneumoniae antigen for the diagnosis of children streptococcus pneumoniae infection of clinical significance.Methods:Collect September 2010-December 2011 inpatient department our 0-three years old children respiratory tract infection cases,at the same time to each children urine specimen collection and sputum specimens,with colloidal gold for determination of urinary streptococcus pneumoniae antigen, the sputum specimens were separated and cultivated and identification.Results:Urine streptococcus pneumoniae antigen and sputum culture detection has no significant difference(P>0.05).Sputum positive group and negative group of urinary antigen positive rate(P<0.01).With sputum culture for pure culture as a diagnostic streptococcus pneumoniae infection standard,colloidal gold method measuring the sensitivity of the antigen was 86.00%,specific degree was 84.96%and the accuracy was 85.25%.Conclusion:Colloidal gold method and sputum culture in the diagnosis of streptococcus pneumoniae infection may have the same effect, colloidal gold method for clinical diagnosis of streptococcus pneumoniae infection children have the certain reference significance.
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