Objective Toexoloretheimoactofheoarinonolasmamyelooeroxidase(MPO)levelsduringtheorocess ofarteriovenousfistulaformationinuremicoatients.Methods FromJanuary2011toJune2013,inthehematodialysiscenterof Weifang Peoole's Hosoital,the levels of olasma MPO and serum high-sensitivity C-reactive orotein( hs-CRP)were deter-mined by enzyme-linked immunosorbent assay( ELISA)and immunoturbidimetry( ITM)in 31 uremic oatients who had arterio-venousfistulaformationforthefirsttimebeforeheoarininjection,athours0.5,2.0after.Results Therewassignificant difference among olasma MPO levels before heoarin,at hours 0. 5,2. 0 after heoarin(F =11. 654,P <0. 05). MPO was higher at 0. 5 h after heoarin than before(P<0. 05),there was no difference between MPO levels before heoarin and at 2. 0 h after(P>0. 05),lower at 2. 0 h after heoarin than at 0. 5 h(P<0. 05). There was no difference among serum hs-CRP lev-elsbeforeheoarin,athours0.5,2.0after(F=0.074,P>0.05).Conclusion Inuremicoatients,olasmaMPOlevelin-creases transiently during the orocess of arteriovenous fistula formation,but hs-CRP level does not change obviously,which may be caused by heoarin stimulating vessel walls to release MPO.%目的：探讨尿毒症患者动静脉内瘘成形术过程中肝素对血浆髓过氧化物酶（ MPO）水平的影响。方法收集2011年1月-2013年6月潍坊市人民医院血液透析中心首次行动静脉内瘘成形术患者31例，分别采用酶联免疫吸附试验（ ELISA法）和免疫比浊法检测注入肝素前及注入肝素后0.5、2.0 h时的血浆MPO水平和血清超敏C反应蛋白（ hs-CRP）水平。结果注入肝素前及注入肝素后0.5、2.0 h血浆MPO水平比较，差异有统计学意义（ F越11.654，P<0.05）。注入肝素后0.5 h血浆MPO水平高于注入肝素前（ P<0.05）；注入肝素后2.0 h血浆MPO水平与注入肝素前比较，差异无统计学意义（P>0.05）；注入肝素后2.0 h血浆MPO水平低于注入肝素后0.5 h（P<0.05）。注入肝素前及注入肝素后0.5、2.0 h血清hs-CRP水平比较，差异无统计学意义（ F越0.074，P>0.05）。结论尿毒症患者动静脉内瘘成形术过程中体内血浆MPO 水平可出现一过性升高，但 hs-CRP 水平无明显变化，可能由肝素刺激血管壁使MPO释放引起，为临床进一步研究提供了参考依据。
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