To investigate the effect of non - pharmacological intervention on blood pressure and vascular active substances in patients with isolated diastolic hypertension ( IDH ). Methods Sixty IDH patients with non - pharmacological intervention to control blood pressure ( IDH group ) and 20 cases healthy people without hypertension ( control group ) were included in this study. Non - pharmacological interventions included the promotion of healthy life styles and the elimination of behaviors that may impact mental and physical health. The blood pressure and vasoactive substances adrenomedullin ( ADM ), prostacyclin ( PGI,2), angiotensin H (AT2), and thromboxane A, (TXA,) levels were detected Before the application of non - pharmacological intervention and 3 and 6 months after inventions. Results The levels of plasma ADM, PGI2, AT,, and TXA, were significantly higher in IDH group than in the control group before non - pharmacological interventions (P<0.05). The decrease of blood pressure was not significant three months after interventions (P> 0.05), but did show significance six months later (P<0.05) in IDH group. Compared with the control group, the levels of plasma ADM, PGI,, AT,, and TXA, showed significant difference three and six months after the non - pharmacological interventions (P<0.05) in IDH group. Conclusion ADM, PGl2, AT,, and TXA2 increase in IDH patients. Non - pharmacological interventions can effectively improve blood pressure and vascular active substances.%目的 探讨非药物治疗对单纯舒张期高血压(IDH)患者血压及血管活性物质的影响.方法 选择60例IDH患者(IDH组)行非药物治疗改善血压,无高血压病且相同年龄的健康者20例作为对照组.非药物治疗主要为改善生活方式、消除不利于心理和身体健康的行为和习惯,包括运动、合理膳食、减轻体质量,减轻精神压力保持平衡心理及戒烟限酒等.在非药物治疗前及治疗后3个月、6个月,监测血压,检测血管活性物质肾上腺髓质素(ADM)、前列环素(PGI2)、血管紧张素Ⅱ(AT2)及血栓素A2(TXA2)水平.结果 治疗前,IDH组ADM、PGI2、AT2、TXA2水平明显高于对照组(P＜0.05).IDH组在非药物治疗3个月后血压较治疗前下降不明显(P＞0.05),非药物治疗6个月后血压较治疗前明显下降(P＜0.05);IDH组ADM、PGI2、AT2、TXA2水平在治疗3个月后及6个月后均较治疗前明显下降(P＜0.05).结论 IDH患者血浆ADM、PGI2、AT2和TXA2水平较对照组升高,非药物治疗3个月后血压下降不明显,治疗后6个月血压明显下降.非药物治疗能够较好地改善IDH患者的血浆ADM、PGI2、AT2、TXA2水平.
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