目的 探讨氧化应激相关指标丙二醛(MDA)、同型半胱氨酸(Hcy)、Ca2+及对氧磷酶-1(PON-1)活性与血管性痴呆(VD)的关系.方法 选取2010-2011年在我院神经内科确诊为VD的住院患者41例(VD组)及我院体检中心体检健康的老年志愿者30例(对照组).对两组进行简易精神状态检查评分(MMSE)和血清MDA、Hcy、Ca2+浓度及PON-1活性检测,并对检测结果进行比较分析.结果 VD组血清MDA和Hcy浓度及PON-1活性与对照组比较,差异均有统计学意义(P＜0.05).VD组血清PON-1活性与MMSE呈正相关(r=0.25,P=0.03),血清Hcy浓度与MMSE呈负相关(r=-0.57,P=0.000),PON-1活性与Hcy浓度亦呈负相关(r=-0.32,P=0.02),MDA浓度与MMSE无相关性(r=0.68,P=0.48).结论 血清MDA、Hcy浓度及PON-1活性的变化可协助诊断VD,且Hcy及PON-1尚可提示病情的进展程度.%Objective To explore the relationship between oxidative stress marks of malondialdehyde ( MDA ), para-oxonase - 1 ( PON - 1 ), homocysteine ( Hey ), Ca2+ and vascular dementia ( VD ). Methods 41 VD patients ( VD group ) admitted to the neurology department in our hospital from 2010 to 2011 and 30 healthy volunteers ( control group ) underwent physical examinations were involved into the study. Mini - Mental State Examination ( MMSE ) scores were graded and the levels of MDA, Hey, Ca2+ and PON - 1 activity were detected and compared between the two groups. Results The levels of MDA, Hey and PON - 1 activity between VD group and control group showed statistically significant differences ( P <0. 05 ). In the VD group, PON - 1 was positively correlated with MMSE ( r = 0. 25 , P = 0. 03 ), Hey was negatively correlated with MMSE ( r = - 0. 57, P = 0. 000 ), PON - 1 activity was negatively correlated with Hey ( r = - 0. 32, P = 0. 02 ), and MDA showed no correlation with MMSE ( r =0. 68, P =0. 48 ). Conclusion The determination of MDA, Hey and PON - 1 activity can help diagnose VD, Hey and PON - 1 can serve as indicators of disease progress.
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